ncx-9 Mitochondrial sodium/calcium exchanger protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ncx-9
Official Full Name: Mitochondrial sodium/calcium exchanger protein
Primary source: WormBase:WBGene00003574
Locus tag: CELE_C13D9.8
See related: AllianceGenome:WB:WBGene00003574
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calcium:sodium antiporter activity. Involved in calcium export from the mitochondrion and regulation of dorsal/ventral axon guidance. Located in mitochondrion. Is expressed in neurons and seam cell. Orthologous to human SLC8B1 (solute carrier family 8 member B1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ncx-9 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 10

Sequence:: Chromosome: V; NC_003283.11 (4991342..4995255, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

our work reveals the specificity by which the handling by NCLX of calcium exchange can map to neural circuit patterning and axon guidance decisions during development
Title: The NCLX-type Na(+)/Ca(2+) Exchanger NCX-9 Is Required for Patterning of Neural Circuits in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C13D9.8 (e-PCR)
- UniSTS:308547

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables calcium:sodium antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium:sodium antiporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium export from the mitochondrion	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in monoatomic cation transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of dorsal/ventral axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Mitochondrial sodium/calcium exchanger protein

NP_504342.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

4991342..4995255 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_071941.3 → NP_504342.2 Mitochondrial sodium/calcium exchanger protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O16242

Conserved Domains (1) summary

PLN03151
Location:68 → 689

PLN03151; cation/calcium exchanger; Provisional