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    mrpl-22 Large ribosomal subunit protein uL22m [ Caenorhabditis elegans ]

    Gene ID: 176482, updated on 9-Dec-2024

    Summary

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    Official Symbol
    mrpl-22
    Official Full Name
    Large ribosomal subunit protein uL22m
    Primary source
    WormBase:WBGene00012645
    Locus tag
    CELE_Y39A1A.6
    See related
    AllianceGenome:WB:WBGene00012645
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in mitochondrion and ribosome. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL22 (mitochondrial ribosomal protein L22). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See mrpl-22 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    4
    Sequence:
    Chromosome: III; NC_003281.10 (10615466..10617859)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Reverse transcriptase domain-containing protein Neighboring gene Rab5 GDP/GTP exchange factor Neighboring gene Secreted protein Neighboring gene eLRR (extracellular Leucine-Rich Repeat) ONly Neighboring gene Cell cycle checkpoint control protein;Cell cycle checkpoint protein hpr-9 Neighboring gene ncRNA Neighboring gene tRNA-Thr

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Large-scale RNAi screens identify novel genes that interact with the C. elegans retinoblastoma pathway as well as splicing-related components with synMuv B activity. Ceron J, et al. BMC Dev Biol, 2007 Apr 6. PMID 17417969, Free PMC Article
    2. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
    3. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
    4. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
    5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of large ribosomal subunit IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ribosome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Large ribosomal subunit protein uL22m
    NP_499340.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10615466..10617859
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066939.6 → NP_499340.1  Large ribosomal subunit protein uL22m [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499340.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9XX18
      Conserved Domains (1) summary
      cd00336
      Location:118 → 223
      Ribosomal_L22; Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper ...
    Nucleotide Protein
    Heading Accession and Version

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