ocr-2 Ion transport domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ocr-2
Official Full Name: Ion transport domain-containing protein
Primary source: WormBase:WBGene00003839
Locus tag: CELE_T09A12.3
See related: AllianceGenome:WB:WBGene00003839
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables temperature-gated cation channel activity. Involved in heat acclimation. Located in non-motile cilium and plasma membrane. Is expressed in several structures, including SMDVL; body ganglion; head neurons; lumbar neurons; and uterus. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease axonal type 2C; keratosis (multiple); motor neuron disease (multiple); osteochondrodysplasia (multiple); and osteonecrosis. Orthologous to several human genes including TRPV5 (transient receptor potential cation channel subfamily V member 5). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ocr-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 13

Sequence:: Chromosome: IV; NC_003282.8 (8213788..8220087, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of both osm-9 and ocr-2 resulted in a robust extension of lifespan up to 32% compared to control C. elegans animals.
Title: TRPV1 pain receptors regulate longevity and metabolism by neuropeptide signaling.
OCR-2 TRPV cation channel may have a direct nuclear function in neuronal cells
Title: A functional nuclear localization sequence in the C. elegans TRPV channel OCR-2.
Loss of GRK-2 function may lead to changes in gene expression, via OSM-9/OCR-2, to selectively alter the levels of signaling components that transduce or regulate bitter taste responses.
Title: Caenorhabditis elegans TRPV channels function in a modality-specific pathway to regulate response to aberrant sensory signaling.
OCR-2, a transient receptor potential vanilloid (TRPV) channel that localizes to the cilia of a subset of neurons, regulates peptide-hormone secretion and L1 starvation survival.
Title: A TRPV channel modulates C. elegans neurosecretion, larval starvation survival, and adult lifespan.
Data report cell-specific regulation of serotonin biosynthesis by the transient receptor potential V (TRPV) ion channels encoded by the osm-9 and ocr-2 genes in C. elegans.
Title: Caenorhabditis elegans TRPV ion channel regulates 5HT biosynthesis in chemosensory neurons.
We identify the molecular basis for the polymodal function of OCR-2 in its native cellular environment.
Title: Polymodal sensory function of the Caenorhabditis elegans OCR-2 channel arises from distinct intrinsic determinants within the protein and is selectively conserved in mammalian TRPV proteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T09A12.3 (e-PCR)
- UniSTS:310749

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables temperature-gated cation channel activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in calcium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in heat acclimation	IDA Inferred from Direct Assay more info	PubMed
involved_in heat acclimation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in heat acclimation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Ion transport domain-containing protein

NP_001299963.1

Confirmed by transcript evidence

NP_501380.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8213788..8220087 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068979.5 → NP_501380.1 Ion transport domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501380.1

Status: REVIEWED

UniProtKB/TrEMBL

O61220

Conserved Domains (2) summary

TIGR00870
Location:137 → 789

trp; transient-receptor-potential calcium channel protein

sd00045
Location:196 → 262

ANK; ANK repeat [structural motif]
NM_001313034.3 → NP_001299963.1 Ion transport domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

A0A0K3AS26

Conserved Domains (1) summary

TIGR00870
Location:93 → 365

trp; transient-receptor-potential calcium channel protein