ppfr-4 Serine/threonine-protein phosphatase 4 regulatory subunit ppfr-4 [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: ppfr-4
Official Full Name: Serine/threonine-protein phosphatase 4 regulatory subunit ppfr-4
Primary source: WormBase:WBGene00022193
Locus tag: CELE_Y71H2B.3
See related: AllianceGenome:WB:WBGene00022193
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable protein phosphatase 2A binding activity and protein phosphatase regulator activity. Involved in embryo development and protein localization to basolateral plasma membrane. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in corpus callosum agenesis-intellectual disability-coloboma-micrognathia syndrome. Orthologous to human IGBP1C (IGBP1 family member C) and IGBP1 (immunoglobulin binding protein 1). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See ppfr-4 in Genome Data Viewer

Location:: chromosome: III

Exon count:: 3

Sequence:: Chromosome: III; NC_003281.10 (2619936..2622709)

Chromosome III - NC_003281.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Y71H2_386.b (e-PCR)
- UniSTS:323797

Y71H2_391.a (e-PCR)
- UniSTS:323802

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase 2A binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase regulator activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in embryo development ending in birth or egg hatching	IGI Inferred from Genetic Interaction more info	PubMed
involved_in meiotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in protein localization to basolateral plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Serine/threonine-protein phosphatase 4 regulatory subunit ppfr-4

NP_001370777.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003281.10 Reference assembly

Range

2619936..2622709

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001384042.2 → NP_001370777.1 Serine/threonine-protein phosphatase 4 regulatory subunit ppfr-4 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9N4E9

Conserved Domains (1) summary

pfam04177
Location:11 → 316

TAP42; TAP42-like family