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    rab-33 Ras-related protein Rab-33 [ Caenorhabditis elegans ]

    Gene ID: 176470, updated on 4-Jan-2025

    Summary

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    Official Symbol
    rab-33
    Official Full Name
    Ras-related protein Rab-33
    Primary source
    WormBase:WBGene00004283
    Locus tag
    CELE_F43D9.2
    See related
    AllianceGenome:WB:WBGene00004283
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable GTP binding activity and GTPase activity. Predicted to be located in plasma membrane. Predicted to be active in Golgi apparatus and endosome. Human ortholog(s) of this gene implicated in Smith-McCort dysplasia 2. Orthologous to several human genes including RAB33B (RAB33B, member RAS oncogene family). [provided by Alliance of Genome Resources, Jan 2025]
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    Genomic context

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    See rab-33 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (10500344..10503853, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene SSD domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TAFII28-like protein domain-containing protein Neighboring gene Ubiquitin-related modifier 1 homolog

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An endocytic pathway as a target of tubby for regulation of fat storage. Mukhopadhyay A, et al. EMBO Rep, 2007 Oct. PMID 17762880, Free PMC Article
    2. Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation. Gomes JE, et al. J Cell Biol, 2013 Aug 5. PMID 23918937, Free PMC Article
    3. ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells. Kao G, et al. Cell, 2007 Feb 9. PMID 17289575
    4. Small GTPases. Lundquist EA. WormBook, 2006 Jan 17. PMID 18050472, Free PMC Article
    5. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ras-related protein Rab-33
    NP_499314.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      10500344..10503853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066913.7 → NP_499314.1  Ras-related protein Rab-33 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_499314.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20365, Q94154
      UniProtKB/TrEMBL
      I7FN77
      Conserved Domains (2) summary
      cd04115
      Location:99 → 270
      Rab33B_Rab33A; Rab GTPase family 33 includes Rab33A and Rab33B
      smart00175
      Location:101 → 270
      RAB; Rab subfamily of small GTPases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20365.1

    Gene LinkOut

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