U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    pgam-5 Serine/threonine-protein phosphatase Pgam5, mitochondrial [ Caenorhabditis elegans ]

    Gene ID: 174231, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    pgam-5
    Official Full Name
    Serine/threonine-protein phosphatase Pgam5, mitochondrial
    Primary source
    WormBase:WBGene00019941
    Locus tag
    CELE_R07G3.5
    See related
    AllianceGenome:WB:WBGene00019941
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in positive regulation of mitochondrial fission and protein dephosphorylation. Predicted to be located in mitochondrial outer membrane. Predicted to be active in mitochondrion. Is expressed in neurons and pharynx. Orthologous to human PGAM5 (PGAM family member 5, mitochondrial serine/threonine protein phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See pgam-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    5
    Sequence:
    Chromosome: II; NC_003280.10 (7597546..7598752, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Rho GTPase-activating protein syd-1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TPR_MLP1_2 domain-containing protein Neighboring gene Osmotic avoidance abnormal protein 8 Neighboring gene LIPaSe related Neighboring gene Uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response. Sheng Y, et al. Geroscience, 2021 Apr. PMID 33527323, Free PMC Article
    2. Balancing mitochondrial biogenesis and mitophagy to maintain energy metabolism homeostasis. Palikaras K, et al. Cell Death Differ, 2015 Sep. PMID 26256515, Free PMC Article
    3. Mitochondrial SKN-1/Nrf mediates a conserved starvation response. Paek J, et al. Cell Metab, 2012 Oct 3. PMID 23040073, Free PMC Article
    4. Mitochondrial phosphoglycerate mutase 5 uses alternate catalytic activity as a protein serine/threonine phosphatase to activate ASK1. Takeda K, et al. Proc Natl Acad Sci U S A, 2009 Jul 28. PMID 19590015, Free PMC Article
    5. Inhibition of mitophagy decreases survival of Caenorhabditis elegans by increasing protein aggregation. Civelek M, et al. Mol Cell Biochem, 2019 Feb. PMID 30094600

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoprotein phosphatase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of mitochondrial fission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein dephosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Serine/threonine-protein phosphatase Pgam5, mitochondrial
    NP_495593.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7597546..7598752 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063192.6 → NP_495593.2  Serine/threonine-protein phosphatase Pgam5, mitochondrial [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495593.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09422
      Conserved Domains (1) summary
      cd07067
      Location:96 → 270
      HP_PGM_like; Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09422.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.