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    rrc-1 GTPase-activating protein rrc-1 [ Caenorhabditis elegans ]

    Gene ID: 181195, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rrc-1
    Official Full Name
    GTPase-activating protein rrc-1
    Primary source
    WormBase:WBGene00009800
    Locus tag
    CELE_F47A4.3
    See related
    AllianceGenome:WB:WBGene00009800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables GTPase activator activity. Involved in positive regulation of GTPase activity. Is expressed in GLRL; GLRR; coelomocyte; excretory cell; and uterine seam cell. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome and coronary artery disease. Orthologous to several human genes including ARHGAP33 (Rho GTPase activating protein 33). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See rrc-1 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    15
    Sequence:
    Chromosome: X; NC_003284.9 (9823752..9831288, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Ligand-gated ion channel 50 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Mediator of RNA polymerase II transcription subunit 12 Neighboring gene tRNA-Ile Neighboring gene Intracellular phospholipase A2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of a novel RhoGAP, RRC-1 of the nematode Caenorhabditis elegans. Delawary M, et al. Biochem Biophys Res Commun, 2007 Jun 1. PMID 17434147
    2. The RhoGAP RRC-1 is required for the assembly or stability of integrin adhesion complexes and is a member of the PIX pathway in muscle. Moody JC, et al. Mol Biol Cell, 2024 Apr 1. PMID 38446619, Free PMC Article
    3. Retromer is required for apoptotic cell clearance by phagocytic receptor recycling. Chen D, et al. Science, 2010 Mar 5. PMID 20133524
    4. Shifted Transversal Design smart-pooling for high coverage interactome mapping. Xin X, et al. Genome Res, 2009 Jul. PMID 19447967, Free PMC Article
    5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables GTPase activator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    GTPase-activating protein rrc-1
    NP_001024683.1
    • Confirmed by transcript evidence
    NP_001024684.1
    • Confirmed by transcript evidence
    NP_001257090.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      9823752..9831288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001029512.5 → NP_001024683.1  GTPase-activating protein rrc-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024683.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20498, Q5WRQ3
      Conserved Domains (3) summary
      cl02563
      Location:41 → 146
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl02570
      Location:276 → 466
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:168 → 238
      SH3; Src Homology 3 domain superfamily

    2. NM_001270161.4 → NP_001257090.1  GTPase-activating protein rrc-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001257090.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C6KRH8
      Conserved Domains (3) summary
      cl02563
      Location:41 → 146
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl02570
      Location:276 → 466
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:168 → 238
      SH3; Src Homology 3 domain superfamily

    3. NM_001029513.6 → NP_001024684.1  GTPase-activating protein rrc-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001024684.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q20498
      Conserved Domains (3) summary
      cl02563
      Location:24 → 129
      PX_domain; The Phox Homology domain, a phosphoinositide binding module
      cl02570
      Location:259 → 449
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
      cl17036
      Location:151 → 221
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q20498.3

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