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    glr-6 Glutamate receptor ionotropic, kainate 2;Ionotropic glutamate receptor C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 180955, updated on 9-Dec-2024

    Summary

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    Official Symbol
    glr-6
    Official Full Name
    Glutamate receptor ionotropic, kainate 2;Ionotropic glutamate receptor C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00001617
    Locus tag
    CELE_F41B4.4
    See related
    AllianceGenome:WB:WBGene00001617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable glutamate receptor activity and transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential. Predicted to be involved in glutamatergic synaptic transmission and modulation of chemical synaptic transmission. Predicted to be located in postsynaptic membrane. Predicted to be active in postsynaptic density membrane. Is expressed in RIAL and RIAR. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See glr-6 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (6836210..6840720, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Secreted protein Neighboring gene Proteobacterial sortase system OmpA family protein Neighboring gene putative ATP synthase subunit g 2, mitochondrial Neighboring gene Antifreeze protein;Prion-like-(Q/N-rich)-domain-bearing protein;Secreted protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular and circuit mechanisms underlying avoidance of rapid cooling stimuli in C. elegans. Lin C, et al. Nat Commun, 2024 Jan 5. PMID 38182628, Free PMC Article
    2. Transmissions of serotonin, dopamine, and glutamate are required for the formation of neurotoxicity from Al2O3-NPs in nematode Caenorhabditis elegans. Li Y, et al. Nanotoxicology, 2013 Aug. PMID 22548316
    3. Glutamate receptor channel signatures. Sprengel R, et al. Trends Pharmacol Sci, 2001 Jan. PMID 11165660
    4. Functional analysis of Caenorhabditis elegans glutamate receptor subunits by domain transplantation. Strutz-Seebohm N, et al. J Biol Chem, 2003 Nov 7. PMID 12930835
    5. Differential expression of glutamate receptor subunits in the nervous system of Caenorhabditis elegans and their regulation by the homeodomain protein UNC-42. Brockie PJ, et al. J Neurosci, 2001 Mar 1. PMID 11222641, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of postsynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Glutamate receptor ionotropic, kainate 2;Ionotropic glutamate receptor C-terminal domain-containing protein
    NP_001370595.1
    • Confirmed by transcript evidence
    NP_741822.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      6836210..6840720 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171712.5 → NP_741822.2  Glutamate receptor ionotropic, kainate 2 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741822.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXV8
      Conserved Domains (2) summary
      cd13714
      Location:409 → 764
      PBP2_iGluR_Kainate; Kainate receptor of the type 2 periplasmic-binding fold superfamily
      cd06368
      Location:21 → 394
      PBP1_iGluR_non_NMDA-like; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the non-NMDA (N-methyl-D-aspartate) subtypes of ionotropic glutamate receptors

    2. NM_001383601.1 → NP_001370595.1  Ionotropic glutamate receptor C-terminal domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MXV7
      Conserved Domains (1) summary
      cl21456
      Location:110 → 248
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein
    Heading Accession and Version

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