U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    gpc-2 G protein gamma domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172396, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    gpc-2
    Official Full Name
    G protein gamma domain-containing protein
    Primary source
    WormBase:WBGene00001682
    Locus tag
    CELE_F08B6.2
    See related
    AllianceGenome:WB:WBGene00001682
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable G-protein beta-subunit binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Is expressed in muscle cell and neurons. Orthologous to human GNG13 (G protein subunit gamma 13). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See gpc-2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    2
    Sequence:
    Chromosome: I; NC_003279.8 (6757763..6758178)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene RRM domain-containing protein Neighboring gene ncRNA Neighboring gene EF-hand domain-containing protein Neighboring gene BPH_3 domain-containing protein Neighboring gene Protein unc-87

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The G-protein beta-subunit GPB-2 in Caenorhabditis elegans regulates the G(o)alpha-G(q)alpha signaling network through interactions with the regulator of G-protein signaling proteins EGL-10 and EAT-16. van der Linden AM, et al. Genetics, 2001 May. PMID 11333232, Free PMC Article
    2. GPC-1, a G protein gamma-subunit, regulates olfactory adaptation in Caenorhabditis elegans. Yamada K, et al. Genetics, 2009 Apr. PMID 19189947, Free PMC Article
    3. Identification of muscle-specific regulatory modules in Caenorhabditis elegans. Zhao G, et al. Genome Res, 2007 Mar. PMID 17284674, Free PMC Article
    4. Presynaptic Gαo (GOA-1) signals to depress command neuron excitability and allow stretch-dependent modulation of egg laying in Caenorhabditis elegans. Ravi B, et al. Genetics, 2021 Aug 9. PMID 34037773, Free PMC Article
    5. Modulation of Caenorhabditis elegans infection sensitivity by the LIN-7 cell junction protein. Sem X, et al. Cell Microbiol, 2012 Oct. PMID 22672310, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables G-protein beta-subunit binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables G-protein beta-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sensory perception of taste IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of heterotrimeric G-protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of heterotrimeric G-protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    G protein gamma domain-containing protein
    NP_491935.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      6757763..6758178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059534.9 → NP_491935.1  G protein gamma domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_491935.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5ECT6
      Conserved Domains (1) summary
      smart00224
      Location:3 → 62
      GGL; G protein gamma subunit-like motifs
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.