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    ugt-8 glucuronosyltransferase [ Caenorhabditis elegans ]

    Gene ID: 186768, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ugt-8
    Official Full Name
    glucuronosyltransferase
    Primary source
    WormBase:WBGene00019234
    Locus tag
    CELE_H23N18.3
    See related
    AllianceGenome:WB:WBGene00019234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable UDP-glycosyltransferase activity. Predicted to be located in membrane. Is expressed in excretory cell; intestine; nervous system; and pharynx. Orthologous to several human genes including UGT2A1 (UDP glucuronosyltransferase family 2 member A1 complex locus); UGT2A2 (UDP glucuronosyltransferase family 2 member A2); and UGT2A3 (UDP glucuronosyltransferase family 2 member A3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ugt-8 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (4903930..4905942)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene glucuronosyltransferase Neighboring gene ncRNA Neighboring gene glucuronosyltransferase Neighboring gene glucuronosyltransferase Neighboring gene glucuronosyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Trauma-induced regulation of VHP-1 modulates the cellular response to mechanical stress. Egge N, et al. Nat Commun, 2021 Mar 5. PMID 33674585, Free PMC Article
    2. The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Mao K, et al. Proc Natl Acad Sci U S A, 2022 Dec 6. PMID 36445965, Free PMC Article
    3. Adaptive and specialised transcriptional responses to xenobiotic stress in Caenorhabditis elegans are regulated by nuclear hormone receptors. Jones LM, et al. PLoS One, 2013. PMID 23922869, Free PMC Article
    4. UDP-glycosyltransferase family in Haemonchus contortus: Phylogenetic analysis, constitutive expression, sex-differences and resistance-related differences. Matoušková P, et al. Int J Parasitol Drugs Drug Resist, 2018 Dec. PMID 30293057, Free PMC Article
    5. Differential expression of genes in C. elegans reveals transcriptional responses to indirect-acting xenobiotic compounds and insensitivity to 2,3,7,8-tetrachlorodibenzodioxin. Karengera A, et al. Ecotoxicol Environ Saf, 2022 Mar 15. PMID 35219257

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables UDP-glycosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucuronosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glycosyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    glucuronosyltransferase
    NP_504315.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      4903930..4905942
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_071914.5 → NP_504315.1  glucuronosyltransferase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_504315.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9TXZ4
      Conserved Domains (2) summary
      PHA03392
      Location:284 → 462
      egt; ecdysteroid UDP-glucosyltransferase; Provisional
      pfam00201
      Location:30 → 516
      UDPGT; UDP-glucoronosyl and UDP-glucosyl transferase
    Nucleotide Protein
    Heading Accession and Version

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