U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    cyp-14A3 CYtochrome P450 family [ Caenorhabditis elegans ]

    Gene ID: 187185, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    cyp-14A3
    Official Full Name
    CYtochrome P450 family
    Primary source
    WormBase:WBGene00010707
    Locus tag
    CELE_K09A11.4
    See related
    AllianceGenome:WB:WBGene00010707
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable several functions, including heme binding activity; iron ion binding activity; and monooxygenase activity. Is expressed in intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in several diseases, including autoimmune hepatitis; extrapyramidal and movement disease; head and neck squamous cell carcinoma; hereditary spastic paraplegia 56; and leukemia (multiple). Orthologous to several human genes including CYP2D6 (cytochrome P450 family 2 subfamily D member 6); CYP2D7 (cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)); and CYP2U1 (cytochrome P450 family 2 subfamily U member 1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See cyp-14A3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    7
    Sequence:
    Chromosome: X; NC_003284.9 (13271837..13274202, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene CYtochrome P450 family Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene PHD-type domain-containing protein Neighboring gene ncRNA Neighboring gene CYtochrome P450 family Neighboring gene ncRNA Neighboring gene tRNA-Thr

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. CYP14 family in Caenorhabditis elegans: Mitochondrial function, detoxification, and lifespan. Lim SYM, et al. J Appl Toxicol, 2024 Nov. PMID 38472099
    2. Development and evaluation of an in vivo assay in Caenorhabditis elegans for screening of compounds for their effect on cytochrome P450 expression. Chakrapani BP, et al. J Biosci, 2008 Jun. PMID 18535361
    3. Cytochrome P450-dependent metabolism of eicosapentaenoic acid in the nematode Caenorhabditis elegans. Kulas J, et al. Arch Biochem Biophys, 2008 Apr 1. PMID 18282462
    4. Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans. Menzel R, et al. J Mol Biol, 2007 Jun 29. PMID 17499272
    5. Differential expression of genes in C. elegans reveals transcriptional responses to indirect-acting xenobiotic compounds and insensitivity to 2,3,7,8-tetrachlorodibenzodioxin. Karengera A, et al. Ecotoxicol Environ Saf, 2022 Mar 15. PMID 35219257

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    CYtochrome P450 family
    NP_510205.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13271837..13274202 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_077804.4 → NP_510205.1  CYtochrome P450 family [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_510205.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q27507
      Conserved Domains (1) summary
      pfam00067
      Location:27 → 483
      p450; Cytochrome P450
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools