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    lron-5 LRRCT domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 184307, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lron-5
    Official Full Name
    LRRCT domain-containing protein
    Primary source
    WormBase:WBGene00008656
    Locus tag
    CELE_F10F2.4
    See related
    AllianceGenome:WB:WBGene00008656
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to be involved in cell development. Predicted to be located in membrane. Is expressed in intestine; nervous system; and tail. Human ortholog(s) of this gene implicated in artery disease (multiple); corneal disease (multiple); and pancreatic cancer. Orthologous to several human genes including FMOD (fibromodulin); KERA (keratocan); and LUM (lumican). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lron-5 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    8
    Sequence:
    Chromosome: III; NC_003281.10 (4623029..4626168)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Lipase Neighboring gene putative phosphoribosylformylglycinamidine synthase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CATP-8/P5A ATPase Regulates ER Processing of the DMA-1 Receptor for Dendritic Branching. Feng Z, et al. Cell Rep, 2020 Sep 8. PMID 32905774
    2. A global analysis of genetic interactions in Caenorhabditis elegans. Byrne AB, et al. J Biol, 2007. PMID 17897480, Free PMC Article
    3. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    LRRCT domain-containing protein
    NP_497943.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      4623029..4626168
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065542.6 → NP_497943.2  LRRCT domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_497943.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q19312
      Conserved Domains (5) summary
      smart00082
      Location:553 → 601
      LRRCT; Leucine rich repeat C-terminal domain
      COG4886
      Location:92 → 272
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      sd00033
      Location:327 → 351
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:72 → 131
      LRR_8; Leucine rich repeat
      NF033189
      Location:345 → 576
      internalin_A; class 1 internalin InlA
    Nucleotide Protein
    Heading Accession and Version

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