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    cht-2 GH18 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174363, updated on 9-Dec-2024

    Summary

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    Official Symbol
    cht-2
    Official Full Name
    GH18 domain-containing protein
    Primary source
    WormBase:WBGene00011757
    Locus tag
    CELE_T13H5.3
    See related
    AllianceGenome:WB:WBGene00011757
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chitin binding activity and hydrolase activity, acting on glycosyl bonds. Predicted to be involved in carbohydrate metabolic process. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See cht-2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    9
    Sequence:
    Chromosome: II; NC_003280.10 (8520925..8523490)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Ribonuclease H2 subunit A Neighboring gene Lipid scramblase CLPTM1L Neighboring gene Matrin-type domain-containing protein Neighboring gene 28S ribosomal protein S18-2, mitochondrial Neighboring gene Sodium/potassium-transporting ATPase subunit beta-1-interacting protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A spatiotemporal reconstruction of the C. elegans pharyngeal cuticle reveals a structure rich in phase-separating proteins. Kamal M, et al. Elife, 2022 Oct 19. PMID 36259463, Free PMC Article
    2. Increasing Complexity of the N-Glycome During Caenorhabditis Development. Wilson IBH, et al. Mol Cell Proteomics, 2023 Mar. PMID 36717059, Free PMC Article
    3. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chitin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    GH18 domain-containing protein
    NP_495798.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      8520925..8523490
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_063397.5 → NP_495798.2  GH18 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_495798.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q22468
      Conserved Domains (3) summary
      cd10909
      Location:418 → 469
      ChtBD1_GH18_2; Hevein or type 1 chitin binding domain (ChtBD1) subfamily; in some members co-occurs with family 18 glycosyl hydrolases
      smart00636
      Location:33 → 376
      Glyco_18; Glyco_18 domain
      cl10447
      Location:35 → 376
      GH18_chitinase-like; The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have ...
    Nucleotide Protein
    Heading Accession and Version

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