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    • Showing Current items.

    acdh-8 medium-chain acyl-CoA dehydrogenase [ Caenorhabditis elegans ]

    Gene ID: 173979, updated on 9-Dec-2024

    Summary

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    Official Symbol
    acdh-8
    Official Full Name
    medium-chain acyl-CoA dehydrogenase
    Primary source
    WormBase:WBGene00019406
    Locus tag
    CELE_K05F1.3
    See related
    AllianceGenome:WB:WBGene00019406
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable medium-chain fatty acyl-CoA dehydrogenase activity. Predicted to be involved in medium-chain fatty acid catabolic process. Predicted to be active in mitochondrion. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in medium chain acyl-CoA dehydrogenase deficiency. Orthologous to human ACADM (acyl-CoA dehydrogenase medium chain). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See acdh-8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (5794495..5796185)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Leukocyte cell-derived chemotaxin-2 homolog Neighboring gene Uncharacterized protein Neighboring gene Major sperm protein 63 Neighboring gene Major sperm protein 19/31/40/45/50/51/53/59/61/65/81/113/142

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Pasteurized Akkermansia muciniphila Reduces Fat Accumulation via nhr-49-Mediated Nuclear Hormone Signaling Pathway in Caenorhabditis elegans. Wu Z, et al. Molecules, 2022 Sep 20. PMID 36234692, Free PMC Article
    2. A bioinformatics approach to elucidate conserved genes and pathways in C. elegans as an animal model for cardiovascular research. Ray AK, et al. Sci Rep, 2024 Mar 29. PMID 38553458, Free PMC Article
    3. Evaluating the adverse effects and mechanisms of nanomaterial exposure on longevity of C. elegans: A literature meta-analysis and bioinformatics analysis of multi-transcriptome data. Yin F, et al. Environ Res, 2024 Apr 15. PMID 38224941
    4. Systems-level transcriptional regulation of Caenorhabditis elegans metabolism. Nanda S, et al. Mol Syst Biol, 2023 May 9. PMID 36942755, Free PMC Article
    5. A Caenorhabditis elegans nutrient response system partially dependent on nuclear receptor NHR-49. Van Gilst MR, et al. Proc Natl Acad Sci U S A, 2005 Sep 20. PMID 16157872, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables flavin adenine dinucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables medium-chain fatty acyl-CoA dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in medium-chain fatty acid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    medium-chain acyl-CoA dehydrogenase
    NP_495142.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      5794495..5796185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_062741.7 → NP_495142.1  medium-chain acyl-CoA dehydrogenase [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21243
      Conserved Domains (2) summary
      COG1960
      Location:21 → 400
      CaiA; Acyl-CoA dehydrogenase related to the alkylation response protein AidB [Lipid transport and metabolism]
      cl09933
      Location:25 → 400
      ACAD; Acyl-CoA dehydrogenase
    Nucleotide Protein
    Heading Accession and Version

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