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    tsp-1 Tetraspanin-1 [ Caenorhabditis elegans ]

    Gene ID: 192096, updated on 27-Dec-2024

    Summary

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    Official Symbol
    tsp-1
    Official Full Name
    Tetraspanin-1
    Primary source
    WormBase:WBGene00006627
    Locus tag
    CELE_C02F5.8
    See related
    AllianceGenome:WB:WBGene00006627
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Involved in innate immune response. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in intestine. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tsp-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    5
    Sequence:
    Chromosome: III; NC_003281.10 (8238001..8239423, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene TetraSPanin family Neighboring gene Putative zinc finger protein C02F5.12 Neighboring gene Proteasome subunit beta type-1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Early-life stress triggers long-lasting organismal resilience and longevity via tetraspanin. Jiang WI, et al. Sci Adv, 2024 Jan 26. PMID 38266092, Free PMC Article
    2. Synapse Formation and Function Across Species: Ancient Roles for CCP, CUB, and TSP-1 Structural Domains. González-Calvo I, et al. Front Neurosci, 2022. PMID 35546877, Free PMC Article
    3. Impaired immune response and barrier function in GSPD-1-deficient C. elegans infected with Klebsiella pneumoniae. Yang WH, et al. Curr Res Microb Sci, 2023. PMID 36798906, Free PMC Article
    4. A conserved role for a GATA transcription factor in regulating epithelial innate immune responses. Shapira M, et al. Proc Natl Acad Sci U S A, 2006 Sep 19. PMID 16968778, Free PMC Article
    5. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Process Evidence Code Pubs
    involved_in innate immune response HEP PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Tetraspanin-1
    NP_498804.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      8238001..8239423 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066403.7 → NP_498804.1  Tetraspanin-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498804.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P34285
      Conserved Domains (2) summary
      pfam00335
      Location:29 → 163
      Tetraspannin; Tetraspanin family
      cl01224
      Location:66 → 131
      DUF805; Protein of unknown function (DUF805)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P34285.1

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