U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    clh-6 Chloride channel protein [ Caenorhabditis elegans ]

    Gene ID: 179655, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    clh-6
    Official Full Name
    Chloride channel protein
    Primary source
    WormBase:WBGene00000533
    Locus tag
    CELE_R07B7.1
    See related
    AllianceGenome:WB:WBGene00000533
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable chloride transmembrane transporter activity. Involved in lysosomal protein catabolic process. Predicted to be located in membrane. Predicted to be active in lysosomal membrane. Is expressed in several structures, including excretory cell; neurons; pharyngeal-intestinal valve; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in autosomal dominant osteopetrosis 2 and autosomal recessive osteopetrosis 4. Orthologous to human CLCN7 (chloride voltage-gated channel 7). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See clh-6 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    10
    Sequence:
    Chromosome: V; NC_003283.11 (12060234..12063368, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene PUM-HD domain-containing protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA Neighboring gene FAD-binding domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Characterization of a novel voltage-dependent outwardly rectifying anion current in Caenorhabditis elegans oocytes. Yin X, et al. Am J Physiol Cell Physiol, 2007 Jan. PMID 16899547
    2. Expression of a CIC chloride channel in Caenorhabditis elegans gamma-aminobutyric acid-ergic neurons. Bianchi L, et al. Neurosci Lett, 2001 Feb 23. PMID 11165764
    3. Into ion channel and transporter function. Caenorhabditis elegans ClC-type chloride channels: novel variants and functional expression. Nehrke K, et al. Am J Physiol Cell Physiol, 2000 Dec. PMID 11078724
    4. CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease. Jentsch TJ, et al. Physiol Rev, 2018 Jul 1. PMID 29845874
    5. Regulators of Lysosome Function and Dynamics in Caenorhabditis elegans. Gee K, et al. G3 (Bethesda), 2017 Mar 10. PMID 28122949, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Lysosomal chloride transporter CLH-6 protects lysosome membrane integrity via cathepsin activation.
      Title: Lysosomal chloride transporter CLH-6 protects lysosome membrane integrity via cathepsin activation.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables chloride transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables voltage-gated chloride channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chloride transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chloride transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lysosomal protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lysosomal membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Chloride channel protein
    NP_506022.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      12060234..12063368 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_073621.6 → NP_506022.1  Chloride channel protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506022.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EC75
      Conserved Domains (3) summary
      cd03685
      Location:70 → 598
      ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...
      cd04591
      Location:620 → 774
      CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
      pfam00654
      Location:168 → 580
      Voltage_CLC; Voltage gated chloride channel
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous