U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ubc-6 E2 ubiquitin-conjugating enzyme [ Caenorhabditis elegans ]

    Gene ID: 174217, updated on 9-Dec-2024

    Summary

    Official Symbol
    ubc-6
    Official Full Name
    E2 ubiquitin-conjugating enzyme
    Primary source
    WormBase:WBGene00006703
    Locus tag
    CELE_D1022.1
    See related
    AllianceGenome:WB:WBGene00006703
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin conjugating enzyme activity. Predicted to be involved in ERAD pathway and protein polyubiquitination. Predicted to be located in membrane. Predicted to be active in nucleus. Is expressed in germ line and oocyte. Orthologous to human UBE2J1 (ubiquitin conjugating enzyme E2 J1). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ubc-6 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    6
    Sequence:
    Chromosome: II; NC_003280.10 (7479187..7480713)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene FYVE-type domain-containing protein Neighboring gene Putative carbonic anhydrase-like protein 2 Neighboring gene ncRNA

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein modification by small protein conjugation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    E2 ubiquitin-conjugating enzyme
    NP_001040755.1
    • Confirmed by transcript evidence
    NP_001040756.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7479187..7480713
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047290.5NP_001040755.1  E2 ubiquitin-conjugating enzyme [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040755.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q18931
      Conserved Domains (2) summary
      PRK10811
      Location:185266
      rne; ribonuclease E; Reviewed
      cd00195
      Location:12121
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
    2. NM_001047291.5NP_001040756.1  E2 ubiquitin-conjugating enzyme [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040756.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B1Q233
      Conserved Domains (2) summary
      PRK10811
      Location:170251
      rne; ribonuclease E; Reviewed
      cd00195
      Location:1106
      UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...