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    xpf-1 ERCC4 domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174793, updated on 9-Dec-2024

    Summary

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    Official Symbol
    xpf-1
    Official Full Name
    ERCC4 domain-containing protein
    Primary source
    WormBase:WBGene00008140
    Locus tag
    CELE_C47D12.8
    See related
    AllianceGenome:WB:WBGene00008140
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables enzyme binding activity. Involved in several processes, including meiotic nuclear division; negative regulation of nematode larval development; and positive regulation of embryonic development. Predicted to be part of nucleotide-excision repair factor 1 complex. Is expressed in several structures, including body wall musculature; germ cell; hypodermis; intestine; and pharyngeal gland cell. Used to study Cockayne syndrome; Fanconi anemia; and xeroderma pigmentosum. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group Q; XFE progeroid syndrome; pancreatic cancer; polyneuropathy due to drug; and xeroderma pigmentosum (multiple). Orthologous to human ERCC4 (ERCC excision repair 4, endonuclease catalytic subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See xpf-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    12
    Sequence:
    Chromosome: II; NC_003280.10 (11696171..11705371)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene CUB domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene Threonine--tRNA ligase, cytoplasmic;threonine--tRNA ligase Neighboring gene inositol-3-phosphate synthase Neighboring gene ncRNA Neighboring gene Malate dehydrogenase Neighboring gene Cyclopropane-fatty-acyl-phospholipid synthase Neighboring gene MARVEL domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. C. elegans whole-genome sequencing reveals mutational signatures related to carcinogens and DNA repair deficiency. Meier B, et al. Genome Res, 2014 Oct. PMID 25030888, Free PMC Article
    2. Analysis of representative mutants for key DNA repair pathways on healthspan in Caenorhabditis elegans. Marchal L, et al. Mech Ageing Dev, 2021 Dec. PMID 34562508, Free PMC Article
    3. Meiotic DNA break repair can utilize homolog-independent chromatid templates in C. elegans. Toraason E, et al. Curr Biol, 2021 Apr 12. PMID 33740427, Free PMC Article
    4. Crossover recombination mediated by HIM-18/SLX4-associated nucleases. Saito TT, et al. Worm, 2014. PMID 25057454, Free PMC Article
    5. Joint molecule resolution requires the redundant activities of MUS-81 and XPF-1 during Caenorhabditis elegans meiosis. O'Neil NJ, et al. PLoS Genet, 2013. PMID 23874209, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1.
      Title: Tissue-Specific DNA Repair Activity of ERCC-1/XPF-1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables damaged DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables single-stranded DNA endodeoxyribonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic chromosome separation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of nematode larval development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide-excision repair involved in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of embryonic development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in resolution of meiotic recombination intermediates IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in resolution of meiotic recombination intermediates IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of nucleotide-excision repair factor 1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ERCC4 domain-containing protein
    NP_496498.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11696171..11705371
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064097.5 → NP_496498.1  ERCC4 domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496498.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G5EBZ1
      Conserved Domains (1) summary
      TIGR00596
      Location:106 → 855
      rad1; DNA repair protein (rad1)
    Nucleotide Protein
    Heading Accession and Version

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