myo-2 Myosin-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: myo-2
Official Full Name: Myosin-2
Primary source: WormBase:WBGene00003514
Locus tag: CELE_T18D3.4
See related: AllianceGenome:WB:WBGene00003514
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable actin filament binding activity and microfilament motor activity. Predicted to be involved in muscle contraction and sarcomere organization. Predicted to be located in sarcomere. Predicted to be part of muscle myosin complex. Predicted to be active in cytoplasm and myosin filament. Is expressed in neurons and pharynx. Human ortholog(s) of this gene implicated in several diseases, including cardiomyopathy (multiple); congenital heart disease (multiple); contractures, pterygia, and spondylocarpotarsal fusion syndrome (multiple); heart conduction disease (multiple); and muscle tissue disease (multiple). Orthologous to several human genes including MYH1 (myosin heavy chain 1); MYH13 (myosin heavy chain 13); and MYH15 (myosin heavy chain 15). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See myo-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (12468061..12475348)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MyHC E706K (E710K in C. elegans) mutation is pathogenic and that the effect is primarily functional rather than structural because thick filaments are formed.
Title: A Caenorhabditis elegans model of the myosin heavy chain IIa E706K [corrected] mutation.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T18D3.4 (e-PCR)
- UniSTS:311632

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal motor activity	IEA Inferred from Electronic Annotation more info
enables microfilament motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microfilament motor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in muscle contraction	ISS Inferred from Sequence or Structural Similarity more info
involved_in sarcomere organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of muscle myosin complex	ISS Inferred from Sequence or Structural Similarity more info
located_in myofibril	IEA Inferred from Electronic Annotation more info
part_of myosin II complex	IBA Inferred from Biological aspect of Ancestor more info
part_of myosin complex	IEA Inferred from Electronic Annotation more info
is_active_in myosin filament	IBA Inferred from Biological aspect of Ancestor more info
located_in myosin filament	IEA Inferred from Electronic Annotation more info
located_in sarcomere	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Myosin-2

NP_510092.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

12468061..12475348

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077691.5 → NP_510092.2 Myosin-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510092.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P12845, Q20439, Q22545

Conserved Domains (4) summary

cd01377
Location:95 → 782

MYSc_class_II; class II myosins, motor domain

pfam00063
Location:83 → 782

Myosin_head; Myosin head (motor domain)

pfam01576
Location:876 → 1939

Myosin_tail_1; Myosin tail

pfam02736
Location:31 → 68

Myosin_N; Myosin N-terminal SH3-like domain