U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    R05G6.10 Ras-GEF domain-containing family member 1B;Ras-GEF domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 177527, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    R05G6.10
    Official Full Name
    Ras-GEF domain-containing family member 1B;Ras-GEF domain-containing protein
    Primary source
    WormBase:WBGene00019902
    Locus tag
    CELE_R05G6.10
    See related
    AllianceGenome:WB:WBGene00019902
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be active in plasma membrane. Is expressed in intestine; neurons; pharynx; and rectal gland cell. Orthologous to several human genes including RASGEF1B (RasGEF domain family member 1B). [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See R05G6.10 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    12
    Sequence:
    Chromosome: IV; NC_003282.8 (7517445..7542535, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene EGF-like domain-containing protein Neighboring gene Venom peptide Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Phospholipid scramblase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Puromycin-sensitive aminopeptidase Neighboring gene Cytidine deaminase Neighboring gene C2H2-type domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
    2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Ras-GEF domain-containing family member 1B;Ras-GEF domain-containing protein
    NP_001294201.1
    • Partially confirmed by transcript evidence
    NP_001294202.1
    • Partially confirmed by transcript evidence
    NP_001294203.1
    • Partially confirmed by transcript evidence
    NP_001368452.1
    • Confirmed by transcript evidence
    NP_501217.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      7517445..7542535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068816.7 → NP_501217.2  Ras-GEF domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_501217.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21758
      Conserved Domains (2) summary
      smart00147
      Location:193 → 446
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:30 → 156
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    2. NM_001307272.4 → NP_001294201.1  Ras-GEF domain-containing family member 1B [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294201.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RS10
      Conserved Domains (2) summary
      smart00147
      Location:279 → 532
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:116 → 242
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    3. NM_001307273.3 → NP_001294202.1  Ras-GEF domain-containing family member 1B [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294202.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RTN2
      Conserved Domains (2) summary
      smart00147
      Location:264 → 517
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:101 → 227
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    4. NM_001307274.3 → NP_001294203.1  Ras-GEF domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001294203.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6SBJ9
      Conserved Domains (2) summary
      smart00147
      Location:221 → 474
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:58 → 184
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

    5. NM_001380329.1 → NP_001368452.1  Ras-GEF domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      W6RY82
      Conserved Domains (2) summary
      smart00147
      Location:110 → 363
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      cl02520
      Location:8 → 73
      REM; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal domain (RasGef_N), also called REM domain (Ras exchanger motif). This domain is common in nucleotide exchange factors for Ras-like small GTPases and is typically found immediately ...
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous