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    asm-3 Putative sphingomyelin phosphodiesterase asm-3;Sphingomyelin phosphodiesterase [ Caenorhabditis elegans ]

    Gene ID: 176879, updated on 9-Dec-2024

    Summary

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    Official Symbol
    asm-3
    Official Full Name
    Putative sphingomyelin phosphodiesterase asm-3;Sphingomyelin phosphodiesterase
    Primary source
    WormBase:WBGene00000213
    Locus tag
    CELE_W03G1.7
    See related
    AllianceGenome:WB:WBGene00000213
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable acid sphingomyelin phosphodiesterase activity. Involved in lipid droplet disassembly. Predicted to be located in extracellular region. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in Niemann-Pick disease; Niemann-Pick disease type A; and Niemann-Pick disease type B. Orthologous to human SMPD1 (sphingomyelin phosphodiesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See asm-3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    13
    Sequence:
    Chromosome: IV; NC_003282.8 (520214..523809, complement)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PB1 domain-containing protein Neighboring gene Maternal embryonic leucine zipper kinase Neighboring gene ncRNA Neighboring gene Ribosomal RNA-processing protein 8 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos. Schmökel V, et al. Genetics, 2016 Mar. PMID 26773047, Free PMC Article
    2. The lipidomes of C. elegans with mutations in asm-3/acid sphingomyelinase and hyl-2/ceramide synthase show distinct lipid profiles during aging. Staab TA, et al. Aging (Albany NY), 2023 Feb 13. PMID 36787434, Free PMC Article
    3. ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target. Kim Y, et al. PLoS One, 2012. PMID 23049887, Free PMC Article
    4. Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans. Goya ME, et al. Cell Rep, 2020 Jan 14. PMID 31940482, Free PMC Article
    5. Subcellular Nanorheology Reveals Lysosomal Viscosity as a Reporter for Lysosomal Storage Diseases. Devany J, et al. Nano Lett, 2018 Feb 14. PMID 29313356

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. cpl-1, ccz-1, and asm-3 are genes required for the processing of lipid-containing droplets in C. elegans embryos
      Title: Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos.
    2. ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target
      Title: ASM-3 acid sphingomyelinase functions as a positive regulator of the DAF-2/AGE-1 signaling pathway and serves as a novel anti-aging target.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables acid sphingomyelin phosphodiesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingomyelin phosphodiesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingomyelin phosphodiesterase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ceramide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in lipid droplet disassembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sphingolipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingomyelin catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sphingomyelin catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingomyelin catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in extracellular region ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Putative sphingomyelin phosphodiesterase asm-3;Sphingomyelin phosphodiesterase
    NP_001040996.1
    • Confirmed by transcript evidence
    NP_001040997.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      520214..523809 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001047531.2 → NP_001040996.1  Putative sphingomyelin phosphodiesterase asm-3 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040996.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9UAY4
      Conserved Domains (3) summary
      smart00741
      Location:20 → 92
      SapB; Saposin (B) Domains
      COG1409
      Location:208 → 462
      CpdA; 3',5'-cyclic AMP phosphodiesterase CpdA [Signal transduction mechanisms]
      cd00842
      Location:135 → 439
      MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain

    2. NM_001047532.6 → NP_001040997.1  Sphingomyelin phosphodiesterase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001040997.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      G8JY85
      Conserved Domains (3) summary
      smart00741
      Location:2 → 48
      SapB; Saposin (B) Domains
      cd00842
      Location:91 → 395
      MPP_ASMase; acid sphingomyelinase and related proteins, metallophosphatase domain
      pfam00149
      Location:151 → 356
      Metallophos; Calcineurin-like phosphoesterase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UAY4.2

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