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    aldo-1 Fructose-bisphosphate aldolase 1 [ Caenorhabditis elegans ]

    Gene ID: 176788, updated on 9-Dec-2024

    Summary

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    Official Symbol
    aldo-1
    Official Full Name
    Fructose-bisphosphate aldolase 1
    Primary source
    WormBase:WBGene00011474
    Locus tag
    CELE_T05D4.1
    See related
    AllianceGenome:WB:WBGene00011474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables fructose-bisphosphate aldolase activity and identical protein binding activity. Predicted to be involved in fructose 1,6-bisphosphate metabolic process and glycolytic process. Located in endoplasmic reticulum; sarcomere; and striated muscle dense body. Is expressed in body wall musculature; enteric muscle; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system; hereditary fructose intolerance syndrome; and type 2 diabetes mellitus. Orthologous to several human genes including ALDOA (aldolase, fructose-bisphosphate A) and ALDOC (aldolase, fructose-bisphosphate C). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See aldo-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (13563346..13564937, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene SCAVenger receptor (CD36 family) related Neighboring gene F-box associated domain-containing protein Neighboring gene Protein PNS1 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Caenorhabditis elegans has two isozymic forms, CE-1 and CE-2, of fructose-1,6-bisphosphate aldolase which are encoded by different genes. Inoue T, et al. Arch Biochem Biophys, 1997 Mar 1. PMID 9056253
    2. Phosphofructokinase relocalizes into subcellular compartments with liquid-like properties in vivo. Jang S, et al. Biophys J, 2021 Apr 6. PMID 32853565, Free PMC Article
    3. Proteasome activity contributes to pro-survival response upon mild mitochondrial stress in Caenorhabditis elegans. Sladowska M, et al. PLoS Biol, 2021 Jul. PMID 34252079, Free PMC Article
    4. Glyceraldehyde-3-phosphate dehydrogenase mediates anoxia response and survival in Caenorhabditis elegans. Mendenhall AR, et al. Genetics, 2006 Nov. PMID 16980394, Free PMC Article
    5. Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis. Lionaki E, et al. Nat Commun, 2022 Feb 3. PMID 35115503, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables fructose-bisphosphate aldolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fructose-bisphosphate aldolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables fructose-bisphosphate aldolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in fructose 1,6-bisphosphate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glycolytic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in heterochromatin ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in sarcomere HDA PubMed 
    located_in striated muscle dense body HDA PubMed 

    General protein information

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    Preferred Names
    Fructose-bisphosphate aldolase 1
    NP_741281.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      13563346..13564937 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_171235.7 → NP_741281.1  Fructose-bisphosphate aldolase 1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_741281.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O45747, P54216
      Conserved Domains (1) summary
      pfam00274
      Location:15 → 365
      Glycolytic; Fructose-bisphosphate aldolase class-I
    Nucleotide Protein
    Heading Accession and Version

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