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    plag-15 PhosphoLipase A2 Group [ Caenorhabditis elegans ]

    Gene ID: 172457, updated on 9-Dec-2024

    Summary

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    Official Symbol
    plag-15
    Official Full Name
    PhosphoLipase A2 Group
    Primary source
    WormBase:WBGene00010872
    Locus tag
    CELE_M05B5.4
    See related
    AllianceGenome:WB:WBGene00010872
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable O-acyltransferase activity. Predicted to be involved in lipid metabolic process. Is expressed in several structures, including intestine; muscle cell; neuronal sheath cell; pharynx; and tail. Human ortholog(s) of this gene implicated in Norum disease and arteriosclerosis. Orthologous to several human genes including PLA2G15 (phospholipase A2 group XV). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See plag-15 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    6
    Sequence:
    Chromosome: I; NC_003279.8 (7188465..7190581)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Ion_trans domain-containing protein Neighboring gene Cytoplasmic protein;Flocculation protein FLO11-like;Uncharacterized protein Neighboring gene Helix-loop-helix protein hlh-2 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. M05B5.4 (lysosomal phospholipase A2) promotes disintegration of autophagic vesicles to maintain C. elegans development. Li Y, et al. Autophagy, 2022 Mar. PMID 34130592, Free PMC Article
    2. Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Holzapfel R, et al. Eur J Cell Biol, 2024 Jun. PMID 38582051
    3. Cytochrome P450s and short-chain dehydrogenases mediate the toxicogenomic response of PCB52 in the nematode Caenorhabditis elegans. Menzel R, et al. J Mol Biol, 2007 Jun 29. PMID 17499272
    4. Lysosome activity is modulated by multiple longevity pathways and is important for lifespan extension in C. elegans. Sun Y, et al. Elife, 2020 Jun 2. PMID 32482227, Free PMC Article
    5. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables O-acyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PhosphoLipase A2 Group
    NP_492033.1
    • Confirmed by transcript evidence;
      Product from WormBase gene class plag

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7188465..7190581
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_059632.6 → NP_492033.1  PhosphoLipase A2 Group [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_492033.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q21515
      Conserved Domains (1) summary
      pfam02450
      Location:71 → 403
      LCAT; Lecithin:cholesterol acyltransferase
    Nucleotide Protein
    Heading Accession and Version

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