ptps-1 Putative 6-pyruvoyl tetrahydrobiopterin synthase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ptps-1
Official Full Name: Putative 6-pyruvoyl tetrahydrobiopterin synthase
Primary source: WormBase:WBGene00015010
Locus tag: CELE_B0041.6
See related: AllianceGenome:WB:WBGene00015010
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables 6-pyruvoyltetrahydropterin synthase activity and identical protein binding activity. Involved in tetrahydrobiopterin biosynthetic process. Predicted to be active in mitochondrion. Is expressed in hypodermis; intestine; and neurons. Human ortholog(s) of this gene implicated in BH4-deficient hyperphenylalaninemia A and phenylketonuria. Orthologous to human PTS (6-pyruvoyltetrahydropterin synthase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ptps-1 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 3

Sequence:: Chromosome: I; NC_003279.8 (4652145..4652906, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

B0041.6 (e-PCR)
- UniSTS:315284

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 6-pyruvoyltetrahydropterin synthase activity	IEA Inferred from Electronic Annotation more info
enables 6-pyruvoyltetrahydropterin synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables lyase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in tetrahydrobiopterin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in tetrahydrobiopterin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Putative 6-pyruvoyl tetrahydrobiopterin synthase

NP_001040626.1

Partially confirmed by transcript evidence

NP_001040627.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4652145..4652906 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047161.2 → NP_001040626.1 Putative 6-pyruvoyl tetrahydrobiopterin synthase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040626.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O02058, Q2MGF4

Conserved Domains (2) summary

pfam01242
Location:11 → 139

PTPS; 6-pyruvoyl tetrahydropterin synthase

cl00263
Location:6 → 139

TFold; Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl ...
NM_001047162.4 → NP_001040627.1 Putative 6-pyruvoyl tetrahydrobiopterin synthase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001040627.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O02058

Conserved Domains (2) summary

pfam01242
Location:8 → 136

PTPS; 6-pyruvoyl tetrahydropterin synthase

cl00263
Location:3 → 136

TFold; Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl ...