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    snx-17 PX domain-containing protein;Sorting nexin-17 homolog [ Caenorhabditis elegans ]

    Gene ID: 184624, updated on 9-Dec-2024

    Summary

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    Official Symbol
    snx-17
    Official Full Name
    PX domain-containing protein;Sorting nexin-17 homolog
    Primary source
    WormBase:WBGene00008927
    Locus tag
    CELE_F17H10.3
    See related
    AllianceGenome:WB:WBGene00008927
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable phosphatidylinositol binding activity. Predicted to be involved in endocytic recycling and intracellular protein transport. Predicted to be located in cytoplasmic vesicle membrane and endosome. Predicted to be active in early endosome. Orthologous to several human genes including SNX17 (sorting nexin 17). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See snx-17 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    13
    Sequence:
    Chromosome: X; NC_003284.9 (13116349..13122291, complement)

    Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene GPI inositol-deacylase Neighboring gene ncRNA Neighboring gene MARVEL domain-containing protein;Transmembrane protein Neighboring gene ncRNA Neighboring gene tRNA-Gly Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Col_cuticle_N domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003284.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SNX-3 mediates retromer-independent tubular endosomal recycling by opposing EEA-1-facilitated trafficking. Tian Y, et al. PLoS Genet, 2021 Jun. PMID 34081703, Free PMC Article
    2. SMGL-1/NBAS acts as a RAB-8 GEF to regulate unconventional protein secretion. Wang X, et al. J Cell Biol, 2022 Jul 4. PMID 35604368, Free PMC Article
    3. A pathway for phagosome maturation during engulfment of apoptotic cells. Kinchen JM, et al. Nat Cell Biol, 2008 May. PMID 18425118, Free PMC Article
    4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endocytic recycling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    PX domain-containing protein;Sorting nexin-17 homolog
    NP_001076762.1
    • Confirmed by transcript evidence
    NP_001076763.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003284.9 Reference assembly

      Range
      13116349..13122291 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001083293.5 → NP_001076762.1  Sorting nexin-17 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076762.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q19532
      Conserved Domains (2) summary
      cd06885
      Location:67 → 173
      PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
      cd13337
      Location:356 → 459
      FERM-like_C_SNX17; Atypical FERM-like domain C-lobe of Sorting nexin 17

    2. NM_001083294.5 → NP_001076763.1  PX domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001076763.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q0G826
      Conserved Domains (3) summary
      cd06885
      Location:3 → 109
      PX_SNX17_31; The phosphoinositide binding Phox Homology domain of Sorting Nexins 17 and 31
      cd13337
      Location:292 → 395
      FERM-like_C_SNX17; Atypical FERM-like domain C-lobe of Sorting nexin 17
      cd16121
      Location:118 → 229
      FERM_F1_SNX17; FERM (Four.1 protein, Ezrin, Radixin, Moesin) domain, F1 sub-domain, found in sorting nexin protein 17 (SNX17)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q19532.2

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