tph-1 Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tph-1
Official Full Name: Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein
Primary source: WormBase:WBGene00006600
Locus tag: CELE_ZK1290.2
See related: AllianceGenome:WB:WBGene00006600
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable tryptophan 5-monooxygenase activity. Involved in several processes, including determination of adult lifespan; locomotory exploration behavior; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in cytosol and neuron projection. Is expressed in several structures, including ASG; CP neuron; nerve ring; pharynx; and serotonergic neurons. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; autistic disorder; borderline personality disorder; and depressive disorder (multiple). Orthologous to human TPH1 (tryptophan hydroxylase 1) and TPH2 (tryptophan hydroxylase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tph-1 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 11

Sequence:: Chromosome: II; NC_003280.10 (7549335..7551983)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The authors show that the interactions between daf-7 and tph-1 regulate redundancy and synergy among neurons in food encoding through coordinated control of circuit-level signal and noise properties.
Title: Genetic control of encoding strategy in a food-sensing neural circuit.
A gene-expression-based neural code for food abundance that modulates lifespan includes daf-7 that primarily regulates gene-expression variability, while tph-1 primarily regulates the dynamic range of gene-expression responses.
Title: A gene-expression-based neural code for food abundance that modulates lifespan.
tph-1 mutants failed to exhibit ethanol interference with gustatory plasticity in Caenorhabditis elegans
Title: Ethanol interferes with gustatory plasticity in Caenorhabditis elegans.

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General gene information

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Markers

ZK1290.2 (e-PCR)
- UniSTS:312481

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen	IEA Inferred from Electronic Annotation more info
enables tryptophan 5-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tryptophan 5-monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables tryptophan 5-monooxygenase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Process	Evidence Code	Pubs
involved_in aromatic amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotory exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of egg-laying behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to axon injury	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to odorant	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in serotonin biosynthetic process from tryptophan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in serotonin biosynthetic process from tryptophan	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of serotonin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein

NP_001359899.1

Confirmed by transcript evidence

NP_495584.4

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

7549335..7551983

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_063183.7 → NP_495584.4 Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_495584.4

Status: REVIEWED

UniProtKB/TrEMBL

G5EED8

Conserved Domains (1) summary

TIGR01270
Location:57 → 532

Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
NM_001373740.3 → NP_001359899.1 Biopterin-dependent aromatic amino acid hydroxylase family profile domain-containing protein [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/TrEMBL

Q2V4U7

Conserved Domains (1) summary

TIGR01270
Location:1 → 429

Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric