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    nirN cytochrome C [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878428, updated on 11-Sep-2024

    Summary

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    Gene symbol
    nirN
    Gene description
    cytochrome C
    Locus tag
    PA0509
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (571111..572592, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene acyl-CoA dehydrogenase Neighboring gene acyl-CoA dehydrogenase Neighboring gene uroporphyrin-III C-methyltransferase Neighboring gene heme d1 biosynthesis protein NirJ Neighboring gene heme d1 biosynthesis protein NirH Neighboring gene heme d1 biosynthesis protein NirG Neighboring gene heme d1 biosynthesis protein NirL

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal Structure of Dihydro-Heme d(1) Dehydrogenase NirN from Pseudomonas aeruginosa Reveals Amino Acid Residues Essential for Catalysis. Klünemann T, et al. J Mol Biol, 2019 Aug 9. PMID 31173777
    2. NirN protein from Pseudomonas aeruginosa is a novel electron-bifurcating dehydrogenase catalyzing the last step of heme d1 biosynthesis. Adamczack J, et al. J Biol Chem, 2014 Oct 31. PMID 25204657, Free PMC Article
    3. Maturation of the cytochrome cd1 nitrite reductase NirS from Pseudomonas aeruginosa requires transient interactions between the three proteins NirS, NirN and NirF. Nicke T, et al. Biosci Rep, 2013 Jun 27. PMID 23683062, Free PMC Article
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Similar to the homodimeric NirS, the monomeric NirN consists of an eight-bladed heme d(1)-binding beta-propeller and a cytochrome c domain, but their relative orientation differs with respect to NirS. His147 coordinates heme d(1) at the proximal side, whereas His323, which belongs to a flexible loop, binds at the distal position.
      Title: Crystal Structure of Dihydro-Heme d(1) Dehydrogenase NirN from Pseudomonas aeruginosa Reveals Amino Acid Residues Essential for Catalysis.
    2. Novel roles for the proteins NirN and NirF during the biosynthesis of heme d1.
      Title: NirN protein from Pseudomonas aeruginosa is a novel electron-bifurcating dehydrogenase catalyzing the last step of heme d1 biosynthesis.
    3. NirS interacts with the potential haem d1 insertion protein NirN in vivo. This NirS-NirN interaction is dependent on the presence of the putative haem d1 biosynthesis enzyme NirF.
      Title: Maturation of the cytochrome cd1 nitrite reductase NirS from Pseudomonas aeruginosa requires transient interactions between the three proteins NirS, NirN and NirF.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within heme biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome C
    NP_249200.1
    • 'Product name confidence: class 3 (Function proposed based on presence of conserved amino acid motif, structural feature or limited sequence similarity to an experimentally studied gene)'

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      571111..572592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249200.1 cytochrome C [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249200.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5E5R6K4
      Conserved Domains (3) summary
      COG2010
      Location:23 → 117
      CccA; Cytochrome c, mono- and diheme variants [Energy production and conversion]
      sd00039
      Location:162 → 201
      7WD40; WD40 repeat [structural motif]
      pfam02239
      Location:128 → 484
      Cytochrom_D1; Cytochrome D1 heme domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9I609.1

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