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    cbrB two-component response regulator CbrB [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 881609, updated on 11-Sep-2024

    Summary

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    Gene symbol
    cbrB
    Gene description
    two-component response regulator CbrB
    Locus tag
    PA4726
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5306989..5308425)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene glutamyl-Q tRNA(Asp) synthetase Neighboring gene hypothetical protein Neighboring gene two-component sensor CbrA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Promoter recognition and activation by the global response regulator CbrB in Pseudomonas aeruginosa. Abdou L, et al. J Bacteriol, 2011 Jun. PMID 21478360, Free PMC Article
    2. Inactivation of CbrAB two-component system hampers root colonization in rhizospheric strain of Pseudomonas aeruginosa PGPR2. Sivakumar R, et al. Biochim Biophys Acta Gene Regul Mech, 2021 Nov-Dec. PMID 34530138
    3. The sensor kinase CbrA is a global regulator that modulates metabolism, virulence, and antibiotic resistance in Pseudomonas aeruginosa. Yeung AT, et al. J Bacteriol, 2011 Feb. PMID 21169488, Free PMC Article
    4. The CbrA-CbrB two-component regulatory system controls the utilization of multiple carbon and nitrogen sources in Pseudomonas aeruginosa. Nishijyo T, et al. Mol Microbiol, 2001 May. PMID 11401699
    5. Regulation of carbon and nitrogen utilization by CbrAB and NtrBC two-component systems in Pseudomonas aeruginosa. Li W, et al. J Bacteriol, 2007 Aug. PMID 17545289, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Inactivation of CbrAB two-component system hampers root colonization in rhizospheric strain of Pseudomonas aeruginosa PGPR2.
      Title: Inactivation of CbrAB two-component system hampers root colonization in rhizospheric strain of Pseudomonas aeruginosa PGPR2.
    2. Here we have identified a conserved palindromic nucleotide sequence that is present in upstream activating sequences (UASs) of promoters under positive control by CbrB and sigma(54) RNA polymerase, especially in the UAS of the crcZ promoter.
      Title: Promoter recognition and activation by the global response regulator CbrB in Pseudomonas aeruginosa.
    3. In summary, this study supports the notion that CbrAB and NtrBC form a network to control the C/N balance in P. aeruginosa.
      Title: Regulation of carbon and nitrogen utilization by CbrAB and NtrBC two-component systems in Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables phosphorelay response regulator activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of proline catabolic process to glutamate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of arginine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of ornithine metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    two-component response regulator CbrB
    NP_253414.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5306989..5308425
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253414.1 two-component response regulator CbrB [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253414.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A3M5EU12
      Conserved Domains (1) summary
      COG2204
      Location:1 → 469
      AtoC; DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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