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    pppA [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879341, updated on 11-Sep-2024

    Summary

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    Official Symbol
    pppA
    Primary source
    PseudoCap:PA0075
    Locus tag
    PA0075
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (90106..90834, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene ABC transporter ATP-binding protein Neighboring gene serine/threonine protein kinase PpkA Neighboring gene hypothetical protein Neighboring gene type VI secretion protein IcmF Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa. Mougous JD, et al. Nat Cell Biol, 2007 Jul. PMID 17558395
    2. Crystal structure of PppA from Pseudomonas aeruginosa, a key regulatory component of type VI secretion systems. Wu Y, et al. Biochem Biophys Res Commun, 2019 Aug 13. PMID 31208722
    3. A eukaryotic-type signalling system of Pseudomonas aeruginosa contributes to oxidative stress resistance, intracellular survival and virulence. Goldová J, et al. BMC Genomics, 2011 Aug 31. PMID 21880152, Free PMC Article
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study reports the first crystal structure of PppA from Pseudomonas aeruginosa, which was determined at a resolution of 2.10A.
      Title: Crystal structure of PppA from Pseudomonas aeruginosa, a key regulatory component of type VI secretion systems.
    2. Oxidative and osmotic stress resistance of P. aeruginosa is affected by the pppA-ppkA mutation. pppA-ppkA mutants are more sensitive to macrophage-mediated killing than the wild-type strain.
      Title: A eukaryotic-type signalling system of Pseudomonas aeruginosa contributes to oxidative stress resistance, intracellular survival and virulence.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables protein serine/threonine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of protein secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine phosphatase
    NP_248765.1
    • Product name confidence: class 1: Function experimentally demonstrated in P. aeruginosa.

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      90106..90834 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_248765.1 serine/threonine phosphatase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_248765.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q9I757
      Conserved Domains (1) summary
      COG0631
      Location:2 → 240
      PTC1; Serine/threonine protein phosphatase PrpC [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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