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    nirS nitrite reductase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882217, updated on 11-Sep-2024

    Summary

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    Gene symbol
    nirS
    Gene description
    nitrite reductase
    Locus tag
    PA0519
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (578394..580100, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene heme d1 biosynthesis protein NirF Neighboring gene cytochrome c55X Neighboring gene cytochrome C-551 Neighboring gene denitrification regulatory protein NirQ Neighboring gene cytochrome C oxidase subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nitrite reductase is critical for Pseudomonas aeruginosa survival during co-infection with the oral commensal Streptococcus parasanguinis. Scoffield JA, et al. Microbiology (Reading), 2016 Feb. PMID 26673783, Free PMC Article
    2. Fine-tuned regulation of the dissimilatory nitrite reductase gene by oxygen and nitric oxide in Pseudomonas aeruginosa. Kuroki M, et al. Environ Microbiol Rep, 2014 Dec. PMID 25186017
    3. NO production by Pseudomonas aeruginosa cd1 nitrite reductase. Cutruzzolà F, et al. IUBMB Life, 2003 Oct-Nov. PMID 14711008
    4. Maturation of the cytochrome cd1 nitrite reductase NirS from Pseudomonas aeruginosa requires transient interactions between the three proteins NirS, NirN and NirF. Nicke T, et al. Biosci Rep, 2013 Jun 27. PMID 23683062, Free PMC Article
    5. Nitrite controls the release of nitric oxide in Pseudomonas aeruginosa cd1 nitrite reductase. Rinaldo S, et al. Biochem Biophys Res Commun, 2007 Nov 23. PMID 17904106

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the results suggest that nitrite reductase plays an important role for survival of P. aeruginosa during co-infection with S. parasanguinis.
      Title: Nitrite reductase is critical for Pseudomonas aeruginosa survival during co-infection with the oral commensal Streptococcus parasanguinis.
    2. NirS is transcribed under low oxygen conditions in an ANR-dependent manner.
      Title: Fine-tuned regulation of the dissimilatory nitrite reductase gene by oxygen and nitric oxide in Pseudomonas aeruginosa.
    3. NirS interacts with the potential haem d1 insertion protein NirN in vivo. This NirS-NirN interaction is dependent on the presence of the putative haem d1 biosynthesis enzyme NirF.
      Title: Maturation of the cytochrome cd1 nitrite reductase NirS from Pseudomonas aeruginosa requires transient interactions between the three proteins NirS, NirN and NirF.
    4. Results demonstrate that the the physiological substrate nitrite displaces NO from the ferrous enzyme.
      Title: Nitrite controls the release of nitric oxide in Pseudomonas aeruginosa cd1 nitrite reductase.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables nitrite reductase (NO-forming) activity TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nitrite reductase
    NP_249210.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      578394..580100 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249210.1 nitrite reductase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249210.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      G8A456
      Conserved Domains (2) summary
      COG2010
      Location:23 → 160
      CccA; Cytochrome c, mono- and diheme variants [Energy production and conversion]
      pfam02239
      Location:170 → 563
      Cytochrom_D1; Cytochrome D1 heme domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P24474.1

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