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    dnr transcriptional regulator Dnr [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882180, updated on 11-Sep-2024

    Summary

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    Gene symbol
    dnr
    Gene description
    transcriptional regulator Dnr
    Locus tag
    PA0527
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (585980..586663, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene denitrification protein NorD Neighboring gene hypothetical protein Neighboring gene ncRNA Neighboring gene transcriptional regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Dynamics of the heme-binding bacterial gas-sensing dissimilative nitrate respiration regulator (DNR) and activation barriers for ligand binding and escape. Lobato L, et al. J Biol Chem, 2014 Sep 19. PMID 25037216, Free PMC Article
    2. A dramatic conformational rearrangement is necessary for the activation of DNR from Pseudomonas aeruginosa. Crystal structure of wild-type DNR. Giardina G, et al. Proteins, 2009 Oct. PMID 19415759
    3. Anaerobic adaptation in Pseudomonas aeruginosa: definition of the Anr and Dnr regulons. Trunk K, et al. Environ Microbiol, 2010 Jun. PMID 20553552
    4. Expression of the nir and nor genes for denitrification of Pseudomonas aeruginosa requires a novel CRP/FNR-related transcriptional regulator, DNR, in addition to ANR. Arai H, et al. FEBS Lett, 1995 Aug 28. PMID 7664887
    5. NO sensing in Pseudomonas aeruginosa: structure of the transcriptional regulator DNR. Giardina G, et al. J Mol Biol, 2008 May 16. PMID 18420222

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High-affinity sequence-specific DNA binding occurs only when DNR heme is nitrosylated, consistent with the proposed function of DNR as nitric oxide sensor.
      Title: Dynamics of the heme-binding bacterial gas-sensing dissimilative nitrate respiration regulator (DNR) and activation barriers for ligand binding and escape.
    2. DNR is able to discriminate in vivo between different diatomic signal molecules, NO and CO, both ligands of the reduced haem iron in vitro, suggesting that DNR responds specifically to NO.
      Title: The transcription factor DNR from Pseudomonas aeruginosa specifically requires nitric oxide and haem for the activation of a target promoter in Escherichia coli.
    3. Data suggests that DNR may undergo an unexpected and very large conformational rearrangement on activation.
      Title: A dramatic conformational rearrangement is necessary for the activation of DNR from Pseudomonas aeruginosa. Crystal structure of wild-type DNR.
    4. Results deascribe the three-dimensional structure of the sensor domain of the DNR from P. aeruginosa at 2.1 A resolution.
      Title: NO sensing in Pseudomonas aeruginosa: structure of the transcriptional regulator DNR.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of oxidoreductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to nitric oxide IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcriptional regulator Dnr
    NP_249218.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      585980..586663 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249218.1 transcriptional regulator Dnr [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249218.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A367MFI3
      Conserved Domains (1) summary
      COG0664
      Location:10 → 221
      Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version

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