U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    mucA sigma factor AlgU negative regulator MucA [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879357, updated on 11-Sep-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    mucA
    Gene description
    sigma factor AlgU negative regulator MucA
    Locus tag
    PA0763
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_002516.2 (831914..832498)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene L-aspartate oxidase Neighboring gene RNA polymerase sigma factor AlgU Neighboring gene sigma factor AlgU regulator MucB Neighboring gene positive regulator for alginate biosynthesis MucC Neighboring gene serine protease MucD

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The anti-sigma factor MucA is required for viability in Pseudomonas aeruginosa. Schofield MC, et al. Mol Microbiol, 2021 Aug. PMID 33905139, Free PMC Article
    2. Control of AlgU, a member of the sigma E-like family of stress sigma factors, by the negative regulators MucA and MucB and Pseudomonas aeruginosa conversion to mucoidy in cystic fibrosis. Schurr MJ, et al. J Bacteriol, 1996 Aug. PMID 8759866, Free PMC Article
    3. [MucA mutation and its alginate-production in clinically isolated Pseudomonas aeruginosa]. Meng J, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2009 Dec. PMID 20045914
    4. Metabolic profiling of Pseudomonas aeruginosa demonstrates that the anti-sigma factor MucA modulates osmotic stress tolerance. Behrends V, et al. Mol Biosyst, 2010 Mar. PMID 20174684
    5. Vanadate and triclosan synergistically induce alginate production by Pseudomonas aeruginosa strain PAO1. Damron FH, et al. Mol Microbiol, 2011 Jul. PMID 21631603, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The anti-sigma factor MucA is required for viability in Pseudomonas aeruginosa.
      Title: The anti-sigma factor MucA is required for viability in Pseudomonas aeruginosa.
    2. Molecular basis of the lipid-induced MucA-MucB dissociation in Pseudomonas aeruginosa.
      Title: Molecular basis of the lipid-induced MucA-MucB dissociation in Pseudomonas aeruginosa.
    3. The structures reveal the molecular basis for MucA recognition by MucB in the periplasm and AlgU in the cytoplasm, thus providing an important step in understanding the mechanisms that regulate a key signal transduction pathway involved in P. aeruginosa pathogenesis.
      Title: Structural basis for the recognition of MucA by MucB and AlgU in Pseudomonas aeruginosa.
    4. mucA gene mutation influenced the virulence of Pseudomonas aeruginosa in P. aeruginosa pneumonia in COPD patients.
      Title: Risk factors for mortality in patients with Pseudomonas aeruginosa pneumonia: Clinical impact of mucA gene mutation.
    5. AlgU controls rsmA transcription and is responsible for RsmA activity in mucA mutant strains.
      Title: Pseudomonas aeruginosa AlgU Contributes to Posttranscriptional Activity by Increasing rsmA Expression in a mucA22 Strain.
    6. Inactivation of mucA (the gene responsible for the mucoid phenotype) in PAO1 leads to p38alpha MAPK activation by both TLR2 and TLR5, as observed in the cystic fibrosis clinical mucoid isolate PACF508.
      Title: Mucoid Pseudomonas aeruginosa caused by mucA mutations result in activation of TLR2 in addition to TLR5 in airway epithelial cells.
    7. Alginate biosynthesis in Pseudomonas aeruginosa is a highly regulated by algU and mucA genes.
      Title: Different mutations in mucA gene of Pseudomonas aeruginosa mucoid strains in cystic fibrosis patients and their effect on algU gene expression.
    8. Alginate induction in PAO1 on Pseudomonas isolation agar with ammonium metavanadate was correlated with increased proteolytic degradation of MucA.
      Title: Vanadate and triclosan synergistically induce alginate production by Pseudomonas aeruginosa strain PAO1.
    9. Genotypic variants of the P. aeruginosa dominant strains can coexist in the chronic colonization in CF patients. These variants can be undetected by RFLP and they might present variable antibiotic susceptibility.
      Title: [Polymorphism of mucA and fpvA genes in Pseudomonas aeruginosa isolates from cystic fibrosis patients: co-existence of genetically different variants].
    10. MucA mutation correlates with the alginate production and phenotype of bacterial colonies.
      Title: [MucA mutation and its alginate-production in clinically isolated Pseudomonas aeruginosa].
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables sigma factor antagonist activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within regulation of polysaccharide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    sigma factor AlgU negative regulator MucA
    NP_249454.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      831914..832498
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249454.1 sigma factor AlgU negative regulator MucA [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249454.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P38107
      Conserved Domains (1) summary
      COG3073
      Location:1 → 194
      RseA; Negative regulator of sigma E activity [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38107.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials