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    fliC B-type flagellin [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882052, updated on 24-Aug-2024

    Summary

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    Gene symbol
    fliC
    Gene description
    B-type flagellin
    Locus tag
    PA1092
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (1183058..1184524)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene hypothetical protein Neighboring gene flagellar glycosyl transferase FgtA Neighboring gene hypothetical protein Neighboring gene B-type flagellar hook-associated protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bivalent flagellin immunotherapy protects mice against Pseudomonas aeruginosa infections in both acute pneumonia and burn wound models. Ahmadi H, et al. Biologicals, 2017 Mar. PMID 28065582
    2. Role of flagella in pathogenesis of Pseudomonas aeruginosa pulmonary infection. Feldman M, et al. Infect Immun, 1998 Jan. PMID 9423837, Free PMC Article
    3. Pseudomonas aeruginosa flagellin and alginate elicit very distinct gene expression patterns in airway epithelial cells: implications for cystic fibrosis disease. Cobb LM, et al. J Immunol, 2004 Nov 1. PMID 15494517
    4. Flagellin of Pseudomonas aeruginosa inhibits Na+ transport in airway epithelia. Kunzelmann K, et al. FASEB J, 2006 Mar. PMID 16410345
    5. New possibility for providing protection against urinary tract infection caused by Pseudomonas aeruginosa by non-adjuvanted flagellin 'b' induced immunity. Sabharwal N, et al. Immunol Lett, 2014 Dec. PMID 25455605

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Studied the presence of virulence genes (B-type flagellin [fliC], exotoxin A [toxA] and phzS) using molecular typing among isolates of Pseudomonas aeruginosa cultured from specimens from diabetic foot. Found fliC, toxA and phzS genes can play important roles in tissue penetration, tissue damage and survival.
      Title: Virulence genes fliC, toxA and phzS are common among Pseudomonas aeruginosa isolates from diabetic foot infections.
    2. Study indicates the roles of FliC phosphorylation in the processes of motility, secretion and biofilm formation and uncovered effects of S/T phosphorylation of FliC on protease secretion by T2SS and biofilm dispersal.
      Title: Flagellin FliC Phosphorylation Affects Type 2 Protease Secretion and Biofilm Dispersal in Pseudomonas aeruginosa PAO1.
    3. Passive immunization with antibodies against flagellin a+b led to an efficacious protection against P. aeruginosa infection in both acute pneumonia and burn models.
      Title: Bivalent flagellin immunotherapy protects mice against Pseudomonas aeruginosa infections in both acute pneumonia and burn wound models.
    4. Flagellin drives NEU1 to desialylate MUC1, thereby increasing its adhesiveness for Pseudomonas aeruginosa and its shedding
      Title: NEU1 Sialidase Regulates Membrane-tethered Mucin (MUC1) Ectodomain Adhesiveness for Pseudomonas aeruginosa and Decoy Receptor Release.
    5. Administration of flagellin 'b' via intraperitoneal route enhanced the clearance of homologous as well as heterologous bacteria (P. aeruginosa uroisolate carrying flagellin 'a') in renal tissue
      Title: New possibility for providing protection against urinary tract infection caused by Pseudomonas aeruginosa by non-adjuvanted flagellin 'b' induced immunity.
    6. Data suggest that the structure-based modeling study on paFliC, the paFliC-TLR5 complex, and the paFliC filament could contribute to the improvement of vaccine design to control P. aeruginosa infection.
      Title: Crystal structure of FliC flagellin from Pseudomonas aeruginosa and its implication in TLR5 binding and formation of the flagellar filament.
    7. Flagellum-deficient (DeltafliC) bacteria produces adequate amounts of exoproteases to degrade SP-A through quorum-sensing.
      Title: The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing.
    8. Flagellin exclusively inhibits the ENaC sodium channel, probably due to release of ATP and activation of purinergic receptors of the P2Y subtype. This activates the MAPK pathway, inhibiting ENaC. Thus, P. aeruginosa reduces Na+ absorption.
      Title: Flagellin of Pseudomonas aeruginosa inhibits Na+ transport in airway epithelia.
    9. The pattern of gene expression directed by flagellin in human airway epithelial cells includes innate host defense genes, proinflammatory cytokines, and chemokines.
      Title: Pseudomonas aeruginosa flagellin and alginate elicit very distinct gene expression patterns in airway epithelial cells: implications for cystic fibrosis disease.
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    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within bacterial-type flagellum-dependent cell motility IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    B-type flagellin
    NP_249783.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      1183058..1184524
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_249783.1 B-type flagellin [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_249783.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A3RJ53
      Conserved Domains (2) summary
      PRK08869
      Location:2 → 488
      PRK08869; polar flagellin E
      pfam07196
      Location:256 → 303
      Flagellin_IN; Flagellin hook IN motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P72151.2

    Gene LinkOut

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