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    hmgA homogentisate 1,2-dioxygenase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 877745, updated on 24-Aug-2024

    Summary

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    Gene symbol
    hmgA
    Gene description
    homogentisate 1,2-dioxygenase
    Locus tag
    PA2009
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2197432..2198730, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene major facilitator superfamily transporter Neighboring gene maleylacetoacetate isomerase Neighboring gene fumarylacetoacetase Neighboring gene transcriptional regulator Neighboring gene 3-hydroxy-3-isohexenylglutaryl-CoA/hydroxy-methylglutaryl-CoA lyase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Homogentisate 1-2-Dioxygenase Downregulation in the Chronic Persistence of Pseudomonas aeruginosa Australian Epidemic Strain-1 in the CF Lung. Harmer CJ, et al. PLoS One, 2015. PMID 26252386, Free PMC Article
    2. Inactivation of the hmgA gene of Pseudomonas aeruginosa leads to pyomelanin hyperproduction, stress resistance and increased persistence in chronic lung infection. Rodríguez-Rojas A, et al. Microbiology (Reading), 2009 Apr. PMID 19332807
    3. Molecular characterization of a gene encoding a homogentisate dioxygenase from Aspergillus nidulans and identification of its human and plant homologues. Fernández-Cañón JM, et al. J Biol Chem, 1995 Sep 8. PMID 7673153
    4. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article
    5. Defining the Pseudomonas aeruginosa SOS response and its role in the global response to the antibiotic ciprofloxacin. Cirz RT, et al. J Bacteriol, 2006 Oct. PMID 17015649, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. This study suggests that hmgA may have a role in P. aeruginosa persistence in chronic infection and the results provide a starting point for clarifying the role of hmgA in chronic Australian Epidemic Strain.[hmgA]
      Title: Homogentisate 1-2-Dioxygenase Downregulation in the Chronic Persistence of Pseudomonas aeruginosa Australian Epidemic Strain-1 in the CF Lung.
    2. Our results clearly demonstrate that hmgA inactivation leads to a better adaptation to chronic lung infection.
      Title: Inactivation of the hmgA gene of Pseudomonas aeruginosa leads to pyomelanin hyperproduction, stress resistance and increased persistence in chronic lung infection.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables homogentisate 1,2-dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within L-phenylalanine catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    homogentisate 1,2-dioxygenase
    NP_250699.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2197432..2198730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_250699.1 homogentisate 1,2-dioxygenase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_250699.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9X4G0
      Conserved Domains (1) summary
      PRK05341
      Location:5 → 432
      PRK05341; homogentisate 1,2-dioxygenase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9X4G0.2

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