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    pvdS extracytoplasmic-function sigma-70 factor [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882839, updated on 24-Aug-2024

    Summary

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    Gene symbol
    pvdS
    Gene description
    extracytoplasmic-function sigma-70 factor
    Locus tag
    PA2426
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2722175..2722738)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene peptide synthase Neighboring gene pyoverdine biosynthesis protein PvdG Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Distinct Modes of Promoter Recognition by Two Iron Starvation σ Factors with Overlapping Promoter Specificities. Agnoli K, et al. J Bacteriol, 2019 Feb 1. PMID 30455278, Free PMC Article
    2. A positive regulatory gene, pvdS, for expression of pyoverdin biosynthetic genes in Pseudomonas aeruginosa PAO. Miyazaki H, et al. Mol Gen Genet, 1995 Jul 22. PMID 7651323
    3. Iron-regulated transcription of the pvdA gene in Pseudomonas aeruginosa: effect of Fur and PvdS on promoter activity. Leoni L, et al. J Bacteriol, 1996 Apr. PMID 8636031, Free PMC Article
    4. Functional analysis of PvdS, an iron starvation sigma factor of Pseudomonas aeruginosa. Leoni L, et al. J Bacteriol, 2000 Mar. PMID 10692351, Free PMC Article
    5. Characterization of an ECF sigma factor protein from Pseudomonas aeruginosa. Wilson MJ, et al. Biochem Biophys Res Commun, 2000 Jul 5. PMID 10873648

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Iron facilitates the RetS-Gac-Rsm cascade to inversely regulate protease IV (piv) expression via the sigma factor PvdS in Pseudomonas aeruginosa.
      Title: Iron facilitates the RetS-Gac-Rsm cascade to inversely regulate protease IV (piv) expression via the sigma factor PvdS in Pseudomonas aeruginosa.
    2. The presence of an A-tract extending downstream from the -35 element at OrbS-dependent promoters was shown to be an important contributor to Burkholderia cenocepacia OrbS specificity, but was not required for the binding of Pseudomonas aeruginosa PvdS.
      Title: Distinct Modes of Promoter Recognition by Two Iron Starvation σ Factors with Overlapping Promoter Specificities.
    3. The LipA (PA2862) but not LipC (PA4813) influences regulation of pyoverdine production and expression of the sigma factor PvdS.
      Title: The lipase LipA (PA2862) but not LipC (PA4813) from Pseudomonas aeruginosa influences regulation of pyoverdine production and expression of the sigma factor PvdS.
    4. Given the role of CysB as master regulator of sulfur metabolism, these results establish a novel molecular link between the iron and sulfur regulons in P. aeruginosa.
      Title: Transcriptional control of the pvdS iron starvation sigma factor gene by the master regulator of sulfur metabolism CysB in Pseudomonas aeruginosa.
    5. The results show that proteolysis and amounts of PvdS are affected by the antisigma factor FpvR and that this activity of FpvR is controlled by the cell surface signaling pathway.
      Title: Role of cell surface signaling in proteolysis of an alternative sigma factor in Pseudomonas aeruginosa.
    6. Pyoverdine signalling does not affect the PvdS cellular content but facilitates PvdS release from the membrane, increasing its cytosolic concentration from 35% in both pvdF and fpvA signalling mutants to 70% in the wild type and 83% in the fpvR mutant.
      Title: Intracellular levels and activity of PvdS, the major iron starvation sigma factor of Pseudomonas aeruginosa.
    7. PvdS may control the transcription of the ptxR, regA and toxA genes, and respond to EO (environemental oxygen) by acting at different levels of the toxA regulatory cascade.
      Title: Regulation of the Pseudomonas aeruginosa toxA, regA and ptxR genes by the iron-starvation sigma factor PvdS under reduced levels of oxygen.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sigma factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sigma factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within positive regulation of secondary metabolite biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of secondary metabolite biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    extracytoplasmic-function sigma-70 factor
    NP_251116.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2722175..2722738
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_251116.1 extracytoplasmic-function sigma-70 factor [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_251116.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      Q51350
      Conserved Domains (1) summary
      PRK07037
      Location:15 → 176
      PRK07037; extracytoplasmic-function sigma-70 factor; Validated
    Nucleotide Protein
    Heading Accession and Version

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