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    mexF resistance-nodulation-cell division (RND) multidrug efflux transporter MexF [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882884, updated on 11-Sep-2024

    Summary

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    Gene symbol
    mexF
    Gene description
    resistance-nodulation-cell division (RND) multidrug efflux transporter MexF
    Locus tag
    PA2494
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (2810009..2813197)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene transcriptional regulator MexT Neighboring gene resistance-nodulation-cell division (RND) multidrug efflux membrane fusion protein MexE Neighboring gene multidrug efflux outer membrane protein OprN Neighboring gene hypothetical protein Neighboring gene transcriptional regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF. Luong PM, et al. J Bacteriol, 2014 Jan. PMID 24244000, Free PMC Article
    2. MexT modulates virulence determinants in Pseudomonas aeruginosa independent of the MexEF-OprN efflux pump. Tian ZX, et al. Microb Pathog, 2009 Oct. PMID 19683048
    3. Transcriptional regulation of the mexEF-oprN multidrug efflux pump operon by MexT and an unidentified repressor in nfxC-type mutant of Pseudomonas aeruginosa. Maseda H, et al. FEMS Microbiol Lett, 2010 Oct. PMID 20727012
    4. Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa. Linares JF, et al. J Bacteriol, 2005 Feb. PMID 15687203, Free PMC Article
    5. Pseudomonas Genome Database: facilitating user-friendly, comprehensive comparisons of microbial genomes. Winsor GL, et al. Nucleic Acids Res, 2009 Jan. PMID 18978025, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Authors show that emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF.
      Title: Emergence of the P2 phenotype in Pseudomonas aeruginosa PAO1 strains involves various mutations in mexT or mexF.
    2. Transcription of the mexEF-oprN multidrug efflux pump operon is regulated by MexT.
      Title: Transcriptional regulation of the mexEF-oprN multidrug efflux pump operon by MexT and an unidentified repressor in nfxC-type mutant of Pseudomonas aeruginosa.
    3. The data presented suggest that MexT regulates diverse targets that mediate phenotypic alterations independent of MexEF-OprN.
      Title: MexT modulates virulence determinants in Pseudomonas aeruginosa independent of the MexEF-OprN efflux pump.
    4. results presented here indicate that the transcriptional activation of the T3S regulon is reduced in mutants overexpressing either the MexCD-OprJ or MexEF-OprN MDR pump, making these mutants less cytotoxic
      Title: Overexpression of the multidrug efflux pumps MexCD-OprJ and MexEF-OprN is associated with a reduction of type III secretion in Pseudomonas aeruginosa.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    resistance-nodulation-cell division (RND) multidrug efflux transporter MexF
    NP_251184.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      2810009..2813197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_251184.1 resistance-nodulation-cell division (RND) multidrug efflux transporter MexF [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_251184.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      P95422
      Conserved Domains (1) summary
      pfam00873
      Location:3 → 1040
      ACR_tran; AcrB/AcrD/AcrF family
    Nucleotide Protein
    Heading Accession and Version

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