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    oprP phosphate-specific outer membrane porin OprP [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 882442, updated on 11-Sep-2024

    Summary

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    Gene symbol
    oprP
    Gene description
    phosphate-specific outer membrane porin OprP
    Locus tag
    PA3279
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (3671227..3672549, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene short-chain dehydrogenase Neighboring gene hypothetical protein Neighboring gene pyrophosphate-specific outer membrane porin OprO Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fosmidomycin transport through the phosphate-specific porins OprO and OprP of Pseudomonas aeruginosa. Piselli C, et al. Mol Microbiol, 2021 Jul. PMID 33561903
    2. Role of the central arginine R133 toward the ion selectivity of the phosphate specific channel OprP: effects of charge and solvation. Modi N, et al. Biochemistry, 2013 Aug 20. PMID 23875754
    3. Probing transport of fosfomycin through substrate specific OprO and OprP from Pseudomonas aeruginosa. Citak F, et al. Biochem Biophys Res Commun, 2018 Jan 1. PMID 29198700
    4. Why do the outer membrane proteins OmpF from E. coli and OprP from P. aeruginosa prefer trimers? Simulation studies. Niramitranon J, et al. J Mol Graph Model, 2016 Apr. PMID 26895142
    5. Structure, Dynamics, and Substrate Specificity of the OprO Porin from Pseudomonas aeruginosa. Modi N, et al. Biophys J, 2015 Oct 6. PMID 26445443, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fosmidomycin transport through the phosphate-specific porins OprO and OprP of Pseudomonas aeruginosa.
      Title: Fosmidomycin transport through the phosphate-specific porins OprO and OprP of Pseudomonas aeruginosa.
    2. Our analyzes show that OprO, and to a lesser degree OprP, have unexpected very high permeability to fosfomycin, so the antibiotic should be a potentially excellent alternative choice for the control of Pseudomonas aeruginosa infections.
      Title: Probing transport of fosfomycin through substrate specific OprO and OprP from Pseudomonas aeruginosa.
    3. The results suggest that trimerization is crucial for both structure and function of general porin OmpF in E. coli, whereas being trimer in substrate-specific channel OprP supports a pore function in Pseudomonas aeruginosa.
      Title: Why do the outer membrane proteins OmpF from E. coli and OprP from P. aeruginosa prefer trimers? Simulation studies.
    4. Study used x-ray crystallography, free-energy molecular dynamics (MD) simulations, and electrophysiology to uncover the atomic basis for the different substrate specificity of OprP and OprO
      Title: Structure, Dynamics, and Substrate Specificity of the OprO Porin from Pseudomonas aeruginosa.
    5. Data indicate the role of the R133 residue - particularly its charge and ability to change the solvation behavior of the permeating ion - in the structure-function relationship of outer membrane porin OprP.
      Title: Role of the central arginine R133 toward the ion selectivity of the phosphate specific channel OprP: effects of charge and solvation.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    phosphate-specific outer membrane porin OprP
    NP_251969.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      3671227..3672549 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_251969.1 phosphate-specific outer membrane porin OprP [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_251969.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A367M642
      Conserved Domains (1) summary
      COG3746
      Location:1 → 440
      OprP; Phosphate-selective porin [Inorganic ion transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P05695.3

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