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    rhlI acyl-homoserine-lactone synthase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878967, updated on 24-Aug-2024

    Summary

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    Gene symbol
    rhlI
    Gene description
    acyl-homoserine-lactone synthase
    Locus tag
    PA3476
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (3889139..3889744, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene chloramphenicol-sensitive protein RarD Neighboring gene hypothetical protein Neighboring gene cyclohexadienyl dehydratase Neighboring gene transcriptional regulator RhlR Neighboring gene rhamnosyltransferase subunit B

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A rhlI 5' UTR-Derived sRNA Regulates RhlR-Dependent Quorum Sensing in Pseudomonas aeruginosa. Thomason MK, et al. mBio, 2019 Oct 8. PMID 31594819, Free PMC Article
    2. Pseudomonas aeruginosa las and rhl quorum-sensing systems are important for infection and inflammation in a rat prostatitis model. Nelson LK, et al. Microbiology (Reading), 2009 Aug. PMID 19460822
    3. Negative regulation of quorum-sensing systems in Pseudomonas aeruginosa by ATP-dependent Lon protease. Takaya A, et al. J Bacteriol, 2008 Jun. PMID 18408026, Free PMC Article
    4. Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization. Haller S, et al. EMBO Rep, 2018 May. PMID 29523648, Free PMC Article
    5. Dynorphin activates quorum sensing quinolone signaling in Pseudomonas aeruginosa. Zaborina O, et al. PLoS Pathog, 2007 Mar. PMID 17367209, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors found that rhlI, which encodes the enzyme that produces the N-butanoyl-homoserine lactone (C4-HSL), is controlled by a 5' untranslated region (UTR)-derived sRNA they name RhlS.
      Title: A rhlI 5' UTR-Derived sRNA Regulates RhlR-Dependent Quorum Sensing in Pseudomonas aeruginosa.
    2. rhlI mutants are unexpectedly more virulent than rhlR mutants, both in fly and in nematode intestinal infection models, suggesting that RhlR has RhlI-independent functions
      Title: Quorum-sensing regulator RhlR but not its autoinducer RhlI enables Pseudomonas to evade opsonization.
    3. The quorum-sensing lasI and rhlI genes in Ps. aeruginosa affect acute prostate infections, but play a considerably more important role in maintaining chronic infections.
      Title: Pseudomonas aeruginosa las and rhl quorum-sensing systems are important for infection and inflammation in a rat prostatitis model.
    4. Data show that RhlR/RhlI was shown to be regulated by Lon independently of LasR/LasI via regulation of RhlI, an HSL synthase.
      Title: Negative regulation of quorum-sensing systems in Pseudomonas aeruginosa by ATP-dependent Lon protease.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    acyl-homoserine-lactone synthase
    NP_252166.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      3889139..3889744 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_252166.1 acyl-homoserine-lactone synthase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_252166.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A411F6V0
      Conserved Domains (1) summary
      COG3916
      Location:1 → 201
      LasI; N-acyl-L-homoserine lactone synthetase [Signal transduction mechanisms]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54291.2

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