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    retS sensor histidine kinase MifS [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 877881, updated on 24-Aug-2024

    Summary

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    Gene symbol
    retS
    Gene description
    sensor histidine kinase MifS
    Locus tag
    PA4856
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5452150..5454978)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Neighboring gene phosphoribosylamine--glycine ligase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mucin Glycans Signal through the Sensor Kinase RetS to Inhibit Virulence-Associated Traits in Pseudomonas aeruginosa. Wang BX, et al. Curr Biol, 2021 Jan 11. PMID 33125866, Free PMC Article
    2. Distinct oligomeric forms of the Pseudomonas aeruginosa RetS sensor domain modulate accessibility to the ligand binding site. Vincent F, et al. Environ Microbiol, 2010 Jun. PMID 20553556
    3. Helix Cracking Regulates the Critical Interaction between RetS and GacS in Pseudomonas aeruginosa. Mancl JM, et al. Structure, 2019 May 7. PMID 30879888
    4. Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa. Francis VI, et al. Nat Commun, 2018 Jun 7. PMID 29880803, Free PMC Article
    5. Characterization of the Direct Interaction between Hybrid Sensor Kinases PA1611 and RetS That Controls Biofilm Formation and the Type III Secretion System in Pseudomonas aeruginosa. Bhagirath AY, et al. ACS Infect Dis, 2017 Feb 10. PMID 27957853

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RetS inhibits Pseudomonas aeruginosa biofilm formation by disrupting the canonical histidine kinase dimerization interface of GacS.
      Title: RetS inhibits Pseudomonas aeruginosa biofilm formation by disrupting the canonical histidine kinase dimerization interface of GacS.
    2. Mucin Glycans Signal through the Sensor Kinase RetS to Inhibit Virulence-Associated Traits in Pseudomonas aeruginosa.
      Title: Mucin Glycans Signal through the Sensor Kinase RetS to Inhibit Virulence-Associated Traits in Pseudomonas aeruginosa.
    3. x-ray crystallography reveals that RetS uses the reversible unfolding of a helix, or helix cracking, to control interactions with GacS
      Title: Helix Cracking Regulates the Critical Interaction between RetS and GacS in Pseudomonas aeruginosa.
    4. Study interactions between two sensor kinases from Pseudomonas aeruginosa, GacS and RetS, which control the switch between acute and chronic virulence demonstrate three mechanisms by which RetS attenuates GacS signalling: RetS takes phosphoryl groups from GacS-P; RetS has transmitter phosphatase activity against the receiver domain of GacS-P; and RetS inhibits GacS autophosphorylation.
      Title: Multiple communication mechanisms between sensor kinases are crucial for virulence in Pseudomonas aeruginosa.
    5. Results from functional studies using RetS identified residues R567 and Q624 to be predominantly involved in the PA1611-RetS interaction and as having a significant effect on the phenotypes.
      Title: Characterization of the Direct Interaction between Hybrid Sensor Kinases PA1611 and RetS That Controls Biofilm Formation and the Type III Secretion System in Pseudomonas aeruginosa.
    6. Independent of phosphate relay, PA1611 interacts directly with RetS in vivo.
      Title: Hybrid sensor kinase PA1611 in Pseudomonas aeruginosa regulates transitions between acute and chronic infection through direct interaction with RetS.
    7. RetS signalling antagonistically controls the type III and type VI secretion systems. The retS mutant displays elevated levels of c-di-GMP.
      Title: The Pseudomonas aeruginosa sensor RetS switches type III and type VI secretion via c-di-GMP signalling.
    8. Data suggest that PhoPQ controls the equilibrium of the small regulatory RNAs and thus fine-tunes the expression of genes in the RetS pathway.
      Title: Magnesium limitation is an environmental trigger of the Pseudomonas aeruginosa biofilm lifestyle.
    9. The study shows that RetS controls both rsmY and rsmZ small RNA expression, whereas HptB exclusively regulates rsmY expression.
      Title: Regulatory RNAs and the HptB/RetS signalling pathways fine-tune Pseudomonas aeruginosa pathogenesis.
    10. Data highlight the modular architecture and assembly of the RetSp fold and give clues on how homodimerization of RetS could be modulated upon ligand binding to control formation of a RetS/GacS heterodimer.
      Title: Distinct oligomeric forms of the Pseudomonas aeruginosa RetS sensor domain modulate accessibility to the ligand binding site.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    sensor histidine kinase MifS
    NP_253543.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5452150..5454978
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253543.1 sensor histidine kinase MifS [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253543.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A367M6T6
      Conserved Domains (3) summary
      PRK11107
      Location:402 → 927
      PRK11107; hybrid sensory histidine kinase BarA; Provisional
      pfam07695
      Location:204 → 390
      7TMR-DISM_7TM; 7TM diverse intracellular signalling
      pfam07696
      Location:50 → 172
      7TMR-DISMED2; 7TMR-DISM extracellular 2
    Nucleotide Protein
    Heading Accession and Version

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