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    mutL DNA mismatch repair protein [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 878468, updated on 24-Aug-2024

    Summary

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    Gene symbol
    mutL
    Gene description
    DNA mismatch repair protein
    Locus tag
    PA4946
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5549780..5551681, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene RNA-binding protein Hfq Neighboring gene tRNA delta(2)-isopentenylpyrophosphate transferase Neighboring gene N-acetylmuramoyl-L-alanine amidase Neighboring gene hypothetical protein Neighboring gene hypothetical protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of DNA structure and sequence requirements for Pseudomonas aeruginosa MutL endonuclease activity. Correa EM, et al. J Biochem, 2013 Dec. PMID 23969026
    2. The mutL mutation in Pseudomonas aeruginosa isolates reveals multidrug-resistant traits and possible evolutionary trends. Wang YM, et al. J Int Med Res, 2010. PMID 21227005
    3. Some amino acids of the Pseudomonas aeruginosa MutL D(Q/M)HA(X)(2)E(X)(4)E conserved motif are essential for the in vivo function of the protein but not for the in vitro endonuclease activity. Correa EM, et al. DNA Repair (Amst), 2011 Nov 10. PMID 21889424
    4. In vitro and in vivo studies of MutS, MutL and MutH mutants: correlation of mismatch repair and DNA recombination. Junop MS, et al. DNA Repair (Amst), 2003 Apr 2. PMID 12606120
    5. DNA mismatch correction in a defined system. Lahue RS, et al. Science, 1989 Jul 14. PMID 2665076

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results showed that PaMutL was able to nick covalently closed circular plasmids but not linear DNA at high ionic strengths, while the activity on linear DNA was only found below 60 mM salt.
      Title: Analysis of DNA structure and sequence requirements for Pseudomonas aeruginosa MutL endonuclease activity.
    2. Some amino acids of the Pseudomonas aeruginosa MutL D(Q/M)HA(X)(2)E(X)(4)E conserved motif are essential for the in vivo function of the protein but not for the in vitro endonuclease activity.
      Title: Some amino acids of the Pseudomonas aeruginosa MutL D(Q/M)HA(X)(2)E(X)(4)E conserved motif are essential for the in vivo function of the protein but not for the in vitro endonuclease activity.
    3. multidrug-resistant (MDR)characteristics and PFGE profiles were clearly correlated with the mutL phylogenetic tree; this indicates that mutations in mutL might contribute to genetic stability in adaptation by changing the MDR traits
      Title: The mutL mutation in Pseudomonas aeruginosa isolates reveals multidrug-resistant traits and possible evolutionary trends.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mismatch repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA mismatch repair protein
    NP_253633.1
    • Product name confidence: class 2 (High similarity to functionally studied protein)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5549780..5551681 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253633.1 DNA mismatch repair protein [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253633.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9HUL8
      Conserved Domains (1) summary
      PRK00095
      Location:5 → 632
      mutL; DNA mismatch repair endonuclease MutL
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9HUL8.1

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