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    pilN type 4 fimbrial biogenesis protein PilN [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 881025, updated on 11-Sep-2024

    Summary

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    Gene symbol
    pilN
    Gene description
    type 4 fimbrial biogenesis protein PilN
    Locus tag
    PA5043
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5679053..5679649, complement)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene type 4 fimbrial biogenesis outer membrane protein PilQ Neighboring gene type 4 fimbrial biogenesis protein PilP Neighboring gene type 4 fimbrial biogenesis protein PilO Neighboring gene type 4 fimbrial biogenesis protein PilM Neighboring gene penicillin-binding protein 1A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM. McCallum M, et al. J Biol Chem, 2016 May 20. PMID 27022027, Free PMC Article
    2. Periplasmic domains of Pseudomonas aeruginosa PilN and PilO form a stable heterodimeric complex. Sampaleanu LM, et al. J Mol Biol, 2009 Nov 20. PMID 19857646
    3. PilMNOPQ from the Pseudomonas aeruginosa type IV pilus system form a transenvelope protein interaction network that interacts with PilA. Tammam S, et al. J Bacteriol, 2013 May. PMID 23457250, Free PMC Article
    4. PilM/N/O/P proteins form an inner membrane complex that affects the stability of the Pseudomonas aeruginosa type IV pilus secretin. Ayers M, et al. J Mol Biol, 2009 Nov 20. PMID 19857645
    5. Type IV Pilus Alignment Subcomplex Proteins PilN and PilO Form Homo- and Heterodimers in Vivo. Leighton TL, et al. J Biol Chem, 2016 Sep 16. PMID 27474743, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data suggest that T4P function depends on rearrangements at PilN and PilO interfaces.
      Title: Type IV Pilus Alignment Subcomplex Proteins PilN and PilO Form Homo- and Heterodimers in Vivo.
    2. Structural analysis, multiangle light scattering coupled with size exclusion chromatography, and bacterial two-hybrid data revealed that PilM forms dimers mediated by the binding of a novel conserved motif in the N terminus of PilM, and binding PilN abrogates this binding interface, resulting in PilM monomerization.
      Title: PilN Binding Modulates the Structure and Binding Partners of the Pseudomonas aeruginosa Type IVa Pilus Protein PilM.
    3. PilP interacts with the N0 segment of PilQ via its C-terminal domain, and that the N-terminal cytoplasmic tail of PilN binds to the actin-like protein PilM, connecting all cellular compartments via the PilMNOPQ protein interaction network.
      Title: PilMNOPQ from the Pseudomonas aeruginosa type IV pilus system form a transenvelope protein interaction network that interacts with PilA.
    4. PilN, PilO and PilP interact directly to form a stable heterotrimeric complex.
      Title: Characterization of the PilN, PilO and PilP type IVa pilus subcomplex.
    5. PilN/O heterodimers form the foundation of the inner-membrane PilM/N/O/P complex, which is critical for the assembly of a functional type IV pili complex.
      Title: Periplasmic domains of Pseudomonas aeruginosa PilN and PilO form a stable heterodimeric complex.
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    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Process Evidence Code Pubs
    acts_upstream_of_or_within type IV pilus assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within type IV pilus-dependent motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in type IV pilus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    type 4 fimbrial biogenesis protein PilN
    NP_253730.1
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5679053..5679649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_253730.1 type 4 fimbrial biogenesis protein PilN [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_253730.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      G3XD30, Q51352
      Conserved Domains (1) summary
      COG3166
      Location:1 → 198
      PilN; Tfp pilus assembly protein PilN [Cell motility, Extracellular structures]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    G3XD30.1

    Gene LinkOut

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    Molecular Biology Databases