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    algC phosphomannomutase [ Pseudomonas aeruginosa PAO1 ]

    Gene ID: 879406, updated on 24-Aug-2024

    Summary

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    Gene symbol
    algC
    Gene description
    phosphomannomutase
    Locus tag
    PA5322
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pseudomonas aeruginosa PAO1 (strain: PAO1)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Pseudomonadales; Pseudomonadaceae; Pseudomonas
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    Genomic context

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    Sequence:
    NC_002516.2 (5991168..5993774)

    NC_002516.2Genomic Context describing neighboring genes Neighboring gene bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase Neighboring gene deoxyuridine 5'-triphosphate nucleotidohydrolase Neighboring gene acetylglutamate kinase Neighboring gene transcriptional regulator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002516.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Post-transcriptional regulation of the virulence-associated enzyme AlgC by the σ(22) -dependent small RNA ErsA of Pseudomonas aeruginosa. Ferrara S, et al. Environ Microbiol, 2015 Jan. PMID 25186153
    2. Synthesis of multiple Pseudomonas aeruginosa biofilm matrix exopolysaccharides is post-transcriptionally regulated. Ma L, et al. Environ Microbiol, 2012 Aug. PMID 22513190, Free PMC Article
    3. The Pseudomonas aeruginosa algC gene encodes phosphoglucomutase, required for the synthesis of a complete lipopolysaccharide core. Coyne MJ Jr, et al. J Bacteriol, 1994 Jun. PMID 7515870, Free PMC Article
    4. Characterization and regulation of the Pseudomonas aeruginosa algC gene encoding phosphomannomutase. Zielinski NA, et al. J Biol Chem, 1991 May 25. PMID 1903398
    5. [The influence of lysogenic phage on biofilm formation of Pseudomonas aeruginosa]. Du BZ, et al. Sichuan Da Xue Xue Bao Yi Xue Ban, 2008 Nov. PMID 19253818

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The results suggest that ErsA and sigma22 combine in an incoherent feed-forward loop to fine-tune AlgC enzyme expression.
      Title: Post-transcriptional regulation of the virulence-associated enzyme AlgC by the σ(22) -dependent small RNA ErsA of Pseudomonas aeruginosa.
    2. The lysogenic phage Ppa3094 could influence biofilm formation by changing the expressing level of the alginate biosynthetic genes AlgC and AlgD.
      Title: [The influence of lysogenic phage on biofilm formation of Pseudomonas aeruginosa].
    3. Two complexes of the enzyme phosphomannomutase/phosphoglucomutase (PMM/PGM) from Pseudomonas aeruginosa with a substrate and an inhibitor have been characterized by X-ray crystallography.
      Title: Complexes of the enzyme phosphomannomutase/phosphoglucomutase with a slow substrate and an inhibitor.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by PseudoCAP

    Function Evidence Code Pubs
    enables phosphoglucomutase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables phosphomannomutase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within O antigen biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within alginic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within lipopolysaccharide core region biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphomannomutase
    NP_254009.2
    • Product name confidence: class 1 (Function experimentally demonstrated in P. aeruginosa)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002516.2 Reference assembly

      Range
      5991168..5993774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_254009.2 phosphomannomutase [Pseudomonas aeruginosa PAO1]

      See identical proteins and their annotated locations for NP_254009.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5E5R135
      Conserved Domains (1) summary
      cd03089
      Location:418 → 857
      PMM_PGM; The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a ...
    Nucleotide Protein
    Heading Accession and Version

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    Molecular Biology Databases