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    UBP11 ubiquitin-specific protease UBP11 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853973, updated on 9-Dec-2024

    Summary

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    Official Symbol
    UBP11
    Official Full Name
    ubiquitin-specific protease UBP11
    Primary source
    SGD:S000001806
    Locus tag
    YKR098C
    See related
    AllianceGenome:SGD:S000001806; FungiDB:YKR098C; VEuPathDB:YKR098C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cysteine-type deubiquitinase activity. Predicted to be involved in regulation of protein stability. Predicted to be active in cytosol and nucleus. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 6. Orthologous to human USP26 (ubiquitin specific peptidase 26) and USP29 (ubiquitin specific peptidase 29). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See UBP11 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (633026..635179, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Esl2p Neighboring gene phosphoenolpyruvate carboxykinase PCK1 Neighboring gene Bas1p Neighboring gene Skg1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. New insights into the regulation of Cystathionine beta synthase (CBS), an enzyme involved in intellectual deficiency in Down syndrome. Conan P, et al. Front Neurosci, 2022. PMID 36711154, Free PMC Article
    2. Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes. Layfield R, et al. Anal Biochem, 1999 Oct 1. PMID 10527495
    3. Ubiquitin pathway proteins influence the mechanism of action of the novel immunosuppressive drug FTY720 in Saccharomyces cerevisiae. Welsch CA, et al. J Biol Chem, 2003 Jul 18. PMID 12709439
    4. Autophagy as a Mechanism for Adaptive Prediction-Mediated Emergence of Drug Resistance. Nivedita N, et al. Front Microbiol, 2021. PMID 34566920, Free PMC Article
    5. Analysis of the deubiquitinating enzymes of the yeast Saccharomyces cerevisiae. Amerik AY, et al. Biol Chem, 2000 Sep-Oct. PMID 11076031

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein deubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein stability IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-specific protease UBP11
    NP_013024.1
    • Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; UBP11 has a paralog, UBP7, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      633026..635179 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179888.1 → NP_013024.1  TPA: ubiquitin-specific protease UBP11 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013024.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXF9, P36026
      UniProtKB/TrEMBL
      B3LRH3, B5VMN9, C8ZCQ7
      Conserved Domains (1) summary
      pfam00443
      Location:298 → 704
      UCH; Ubiquitin carboxyl-terminal hydrolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36026.1

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