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    ACSL6 acyl-CoA synthetase long chain family member 6 [ Homo sapiens (human) ]

    Gene ID: 23305, updated on 4-Jan-2025

    Summary

    Official Symbol
    ACSL6provided by HGNC
    Official Full Name
    acyl-CoA synthetase long chain family member 6provided by HGNC
    Primary source
    HGNC:HGNC:16496
    See related
    Ensembl:ENSG00000164398 MIM:604443; AllianceGenome:HGNC:16496
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACS2; FACL6; LACS2; LACS5; LACS 6
    Summary
    The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
    Expression
    Biased expression in brain (RPKM 19.2), testis (RPKM 8.4) and 5 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ACSL6 in Genome Data Viewer
    Location:
    5q31.1
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (131949973..132012213, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (132469856..132532085, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (131285666..131347906, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene folliculin interacting protein 1 Neighboring gene ACTB pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23059 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16308 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16309 Neighboring gene meiotic kinetochore factor Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:131267911-131268464 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:131293433-131293633 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:131329699-131330242 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:131330787-131331330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:131337447-131338042 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16310 Neighboring gene uncharacterized LOC124901062 Neighboring gene ACSL6 antisense RNA 1 Neighboring gene MPRA-validated peak5463 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16311 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:131366011-131366190 Neighboring gene uncharacterized LOC105379174 Neighboring gene enhancer-blocking elements downstream of IL3 Neighboring gene interleukin 3 Neighboring gene colony stimulating factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (9 hits/1261 screens)

    EBI GWAS Catalog

    Description
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of acyl-CoA synthetase long-chain family member 6 (ACSL6) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    General gene information

    Potential readthrough

    Included gene: MEIKIN

    Clone Names

    • FLJ16173, KIAA0837, DKFZp547D104

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding  
    enables arachidonate-CoA ligase activity  
    enables arachidonate-CoA ligase activity  
    enables enzyme binding PubMed 
    enables long-chain fatty acid-CoA ligase activity PubMed 
    enables long-chain fatty acid-CoA ligase activity PubMed 
    enables long-chain fatty acid-CoA ligase activity PubMed 
    enables long-chain fatty acid-CoA ligase activity  
    enables protein binding PubMed 
    enables protein homodimerization activity PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum  
    located_in endoplasmic reticulum PubMed 
    located_in endoplasmic reticulum membrane  
    is_active_in membrane  
    located_in membrane PubMed 
    located_in mitochondrial outer membrane  
    located_in peroxisomal membrane  
    located_in plasma membrane PubMed 

    General protein information

    Preferred Names
    long-chain-fatty-acid--CoA ligase 6
    Names
    arachidonate--CoA ligase
    fatty-acid-Coenzyme A ligase, long-chain 6
    long fatty acyl-CoA synthetase 2
    NP_001009185.1
    NP_001192176.1
    NP_001192177.1
    NP_001192179.1
    NP_001192180.1
    NP_001392404.1
    NP_001392405.1
    NP_001392406.1
    NP_001392407.1
    NP_001392408.1
    NP_001392409.1
    NP_001392410.1
    NP_001392411.1
    NP_001392412.1
    NP_001392413.1
    NP_001392414.1
    NP_001392415.1
    NP_001392416.1
    NP_001392417.1
    NP_001392418.1
    NP_001392419.1
    NP_056071.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028290.2 RefSeqGene

      Range
      5411..67096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001009185.3 → NP_001009185.1  long-chain-fatty-acid--CoA ligase 6 isoform b

      See identical proteins and their annotated locations for NP_001009185.1

      Status: REVIEWED

      Source sequence(s)
      AB020644, AC034228, BM992189, DA200154
      Consensus CDS
      CCDS34229.1
      UniProtKB/TrEMBL
      B2RB13
      Related
      ENSP00000499063.2, ENST00000651883.2
      Conserved Domains (2) summary
      PLN02736
      Location:97 → 719
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:141 → 718
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    2. NM_001205247.2 → NP_001192176.1  long-chain-fatty-acid--CoA ligase 6 isoform c

      Status: REVIEWED

      Source sequence(s)
      AB020644, AC034228, AK294291, BM992189, DA200154
      UniProtKB/TrEMBL
      B4DFW3
      Conserved Domains (2) summary
      PLN02736
      Location:62 → 684
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:106 → 683
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    3. NM_001205248.2 → NP_001192177.1  long-chain-fatty-acid--CoA ligase 6 isoform d

      See identical proteins and their annotated locations for NP_001192177.1

      Status: REVIEWED

      Source sequence(s)
      AB020644, AC034228, AK314452, BI464352, BM992189
      Consensus CDS
      CCDS56381.1
      UniProtKB/TrEMBL
      B2RB13
      Conserved Domains (2) summary
      PLN02736
      Location:72 → 694
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:116 → 693
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    4. NM_001205250.1 → NP_001192179.1  long-chain-fatty-acid--CoA ligase 6 isoform e

      Status: REVIEWED

      Source sequence(s)
      AB020644, AC034228, BM992189, DA801862
      Consensus CDS
      CCDS56383.1
      UniProtKB/TrEMBL
      B2RB13
      Related
      ENSP00000368548.1, ENST00000379246.5
      Conserved Domains (2) summary
      PLN02736
      Location:83 → 705
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:127 → 704
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    5. NM_001205251.2 → NP_001192180.1  long-chain-fatty-acid--CoA ligase 6 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC034228, AK314452, BC047453, BI464352, BM992189
      Consensus CDS
      CCDS56382.1
      UniProtKB/TrEMBL
      E7ERD7
      Related
      ENSP00000349608.1, ENST00000357096.5
      Conserved Domains (2) summary
      PLN02736
      Location:37 → 619
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:81 → 618
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)
    6. NM_001405475.1 → NP_001392404.1  long-chain-fatty-acid--CoA ligase 6 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/TrEMBL
      A0A494C0B6, B2RB13
      Related
      ENSP00000498444.1, ENST00000650697.1
    7. NM_001405476.1 → NP_001392405.1  long-chain-fatty-acid--CoA ligase 6 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/TrEMBL
      B2RB13
    8. NM_001405477.1 → NP_001392406.1  long-chain-fatty-acid--CoA ligase 6 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/TrEMBL
      A0A499FJL5, B2RB13
      Related
      ENSP00000296869.5, ENST00000296869.9
    9. NM_001405478.1 → NP_001392407.1  long-chain-fatty-acid--CoA ligase 6 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/TrEMBL
      B2RB13
    10. NM_001405479.1 → NP_001392408.1  long-chain-fatty-acid--CoA ligase 6 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/Swiss-Prot
      J3KPG3, O94924, O95829, Q108M9, Q108N0, Q4G191, Q86TN7, Q9UKU0
      UniProtKB/TrEMBL
      B2RB13
    11. NM_001405480.1 → NP_001392409.1  long-chain-fatty-acid--CoA ligase 6 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/Swiss-Prot
      J3KPG3, O94924, O95829, Q108M9, Q108N0, Q4G191, Q86TN7, Q9UKU0
      UniProtKB/TrEMBL
      B2RB13
      Related
      ENSP00000442124.2, ENST00000543479.5
    12. NM_001405481.1 → NP_001392410.1  long-chain-fatty-acid--CoA ligase 6 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/TrEMBL
      B2RB13
      Related
      ENSP00000368546.1, ENST00000379244.5
    13. NM_001405482.1 → NP_001392411.1  long-chain-fatty-acid--CoA ligase 6 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/Swiss-Prot
      J3KPG3, O94924, O95829, Q108M9, Q108N0, Q4G191, Q86TN7, Q9UKU0
      UniProtKB/TrEMBL
      B2RB13
    14. NM_001405483.1 → NP_001392412.1  long-chain-fatty-acid--CoA ligase 6 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/Swiss-Prot
      J3KPG3, O94924, O95829, Q108M9, Q108N0, Q4G191, Q86TN7, Q9UKU0
      UniProtKB/TrEMBL
      B2RB13
      Related
      ENSP00000368542.1, ENST00000379240.5
    15. NM_001405484.1 → NP_001392413.1  long-chain-fatty-acid--CoA ligase 6 isoform d

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/TrEMBL
      B2RB13
    16. NM_001405485.1 → NP_001392414.1  long-chain-fatty-acid--CoA ligase 6 isoform l

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/TrEMBL
      B4DFW3, C9J8C7
      Related
      ENSP00000397507.2, ENST00000434099.6
    17. NM_001405486.1 → NP_001392415.1  long-chain-fatty-acid--CoA ligase 6 isoform m

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/TrEMBL
      A0A494C0J9, B4DFW3
      Related
      ENSP00000498588.1, ENST00000651250.1
    18. NM_001405487.1 → NP_001392416.1  long-chain-fatty-acid--CoA ligase 6 isoform n

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/TrEMBL
      E7ERD7
    19. NM_001405488.1 → NP_001392417.1  long-chain-fatty-acid--CoA ligase 6 isoform n

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/TrEMBL
      E7ERD7
      Related
      ENSP00000413329.1, ENST00000431707.5
    20. NM_001405489.1 → NP_001392418.1  long-chain-fatty-acid--CoA ligase 6 isoform o

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/TrEMBL
      A0A494BZW8, E7ERD7
      Related
      ENSP00000498263.1, ENST00000651427.1
    21. NM_001405490.1 → NP_001392419.1  long-chain-fatty-acid--CoA ligase 6 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC034228
      UniProtKB/TrEMBL
      E7ERD7
      Related
      ENSP00000368557.1, ENST00000379255.5
    22. NM_015256.4 → NP_056071.2  long-chain-fatty-acid--CoA ligase 6 isoform a

      Status: REVIEWED

      Source sequence(s)
      AB020644, AC034228, AK294291, BM992189, DA200154
      Consensus CDS
      CCDS34228.1
      UniProtKB/TrEMBL
      B2RB13
      Related
      ENSP00000498260.1, ENST00000651356.1
      Conserved Domains (2) summary
      PLN02736
      Location:97 → 719
      PLN02736; long-chain acyl-CoA synthetase
      cd05927
      Location:141 → 718
      LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

    RNA

    1. NR_175945.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC034228
    2. NR_175946.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC034228
    3. NR_175947.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC034228

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      131949973..132012213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      132469856..132532085 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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