RPS20 ribosomal protein S20 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPS20provided by HGNC
Official Full Name: ribosomal protein S20provided by HGNC
Primary source: HGNC:HGNC:10405
See related: Ensembl:ENSG00000008988 MIM:603682; AllianceGenome:HGNC:10405
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: S20; uS10
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S10P family of ribosomal proteins. It is located in the cytoplasm. This gene is co-transcribed with the small nucleolar RNA gene U54, which is located in its second intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Two transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Apr 2009]
Expression: Ubiquitous expression in ovary (RPKM 727.4), fat (RPKM 436.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q12.1

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (56067254..56074506, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (56444256..56451508, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (56979813..56987065, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deficiency of the ribosomal protein uS10 (RPS20) reorganizes human cells translatome according to the abundance, CDS length and GC content of mRNAs.
Title: Deficiency of the ribosomal protein uS10 (RPS20) reorganizes human cells translatome according to the abundance, CDS length and GC content of mRNAs.
Prospective study: expression levels of microRNA-7-3p and its target STAT3 in head and neck cancer.
Title: Prospective study: expression levels of microRNA-7-3p and its target STAT3 in head and neck cancer.
Biochemical and clinical effects of RPS20 expression in renal clear cell carcinoma.
Title: Biochemical and clinical effects of RPS20 expression in renal clear cell carcinoma.
Expansion of germline RPS20 mutation phenotype to include Diamond-Blackfan anemia.
Title: Expansion of germline RPS20 mutation phenotype to include Diamond-Blackfan anemia.
A novel ribosomal protein S20 variant in a family with unexplained colorectal cancer and polyposis.
Title: A novel ribosomal protein S20 variant in a family with unexplained colorectal cancer and polyposis.
cross-talk between GNL1 and RPS20 is critical to promote cell proliferation.
Title: Interplay between human nucleolar GNL1 and RPS20 is critical to modulate cell proliferation.
We therefore found published evidence to support the association between variants in NTHL1 and RPS20 with CRC.
Title: Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients-a Systematic Review.
increased expression of RPS11 and RPS20 predicts shorter patient survival. treatment-resistant GSC clones are clinically relevant cells that represent resistant tumorigenic clones from patient tumors and that their properties
Title: Ribosomal Proteins RPS11 and RPS20, Two Stress-Response Markers of Glioblastoma Stem Cells, Are Novel Predictors of Poor Prognosis in Glioblastoma Patients.
Mutations in RPS20 can predispose individuals to microsatellite-stable hereditary nonpolyposis colorectal carcinoma.
Title: Germline mutation of RPS20, encoding a ribosomal protein, causes predisposition to hereditary nonpolyposis colorectal carcinoma without DNA mismatch repair deficiency.
RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network but employ different mechanisms to do so.
Title: Ribosomal proteins RPL37, RPS15 and RPS20 regulate the Mdm2-p53-MdmX network.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response Haploinsufficency No evidence available (Last evaluated 2024-12-12) ClinGen Genome Curation Page Triplosensitivity No evidence available (Last evaluated 2024-12-12) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Many sequence variants affecting diversity of adult human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Nef	nef	HIV-1 Nef immunocomplexes analyzed by mass spectrometry reveal that ribosomal protein S20 (RPS20) is a Nef-binding protein in Jurkat cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S1961 (e-PCR)
- UniSTS:69381

RPS20 (e-PCR)
- UniSTS:504327

D3S3911 (e-PCR)
- UniSTS:7262

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables MDM2/MDM4 family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA binding	HDA more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	HDA more info	PubMed
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	NAS Non-traceable Author Statement more info	PubMed
enables ubiquitin ligase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of signal transduction by p53 class mediator	IDA Inferred from Direct Assay more info	PubMed
involved_in translation	IC Inferred by Curator more info	PubMed
involved_in translation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	HDA more info	PubMed
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: small ribosomal subunit protein uS10

Names: 40S ribosomal protein S20

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_042872.1 RefSeqGene

Range

5076..6528

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001023.4 → NP_001014.1 small ribosomal subunit protein uS10 isoform 2

See identical proteins and their annotated locations for NP_001014.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.

Source sequence(s)

BC007507, CB138358

Consensus CDS

CCDS6163.1

UniProtKB/Swiss-Prot

B2R4F4, B4DW28, P17075, P60866, Q5M8S9

Related

ENSP00000009589.3, ENST00000009589.8

Conserved Domains (1) summary

cl00314
Location:16 → 116

Ribosomal_S10; Ribosomal protein S10p/S20e
NM_001146227.3 → NP_001139699.1 small ribosomal subunit protein uS10 isoform 1

See identical proteins and their annotated locations for NP_001139699.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC107376, AK301342, CD671362

Consensus CDS

CCDS55231.1

UniProtKB/TrEMBL

A0A7P0S5H5

Related

ENSP00000429374.1, ENST00000519807.5

Conserved Domains (1) summary

cl00314
Location:16 → 112

Ribosomal_S10; Ribosomal protein S10p/S20e