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    SIRT5 sirtuin 5 [ Homo sapiens (human) ]

    Gene ID: 23408, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SIRT5provided by HGNC
    Official Full Name
    sirtuin 5provided by HGNC
    Primary source
    HGNC:HGNC:14933
    See related
    Ensembl:ENSG00000124523 MIM:604483; AllianceGenome:HGNC:14933
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SIR2L5
    Summary
    This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]
    Expression
    Ubiquitous expression in heart (RPKM 3.7), liver (RPKM 2.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SIRT5 in Genome Data Viewer
    Location:
    6p23
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (13574274..13615158)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (13447831..13488715)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (13574506..13615390)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24036 Neighboring gene ribosomal protein S4X pseudogene 7 Neighboring gene RN7SK pseudogene 204 Neighboring gene uncharacterized LOC105374937 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:13574598-13575184 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:13575185-13575770 Neighboring gene uncharacterized LOC105374938 Neighboring gene uncharacterized LOC124901263 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24038 Neighboring gene nucleolar protein 7 Neighboring gene RAN binding protein 9 Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue distribution, subcellular localization, and enzymatic activity analysis of human SIRT5 isoforms. Du Y, et al. Biochem Biophys Res Commun, 2018 Sep 5. PMID 29932920
    2. Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme. Yu J, et al. PLoS One, 2016. PMID 27023330, Free PMC Article
    3. Sirtuin 5 is Anti-apoptotic and Anti-oxidative in Cultured SH-EP Neuroblastoma Cells. Liang F, et al. Neurotox Res, 2017 Jan. PMID 27577743
    4. SIRT5 Directly Inhibits the PI3K/AKT Pathway in Prostate Cancer Cell Lines. Choi SY, et al. Cancer Genomics Proteomics, 2022 Jan-Feb. PMID 34949659, Free PMC Article
    5. SIRT5 functions as a tumor suppressor in renal cell carcinoma by reversing the Warburg effect. Yihan L, et al. J Transl Med, 2021 Dec 20. PMID 34930316, Free PMC Article

    See all (132) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SIRT5-mediated PRKAA2 succinylation ameliorates apoptosis of human placental trophoblasts in hypertensive disorder complicating pregnancy.
      Title: SIRT5-mediated PRKAA2 succinylation ameliorates apoptosis of human placental trophoblasts in hypertensive disorder complicating pregnancy.
    2. Sirtuin 5-mediated deacetylation of TAZ at K54 promotes melanoma development.
      Title: Sirtuin 5-mediated deacetylation of TAZ at K54 promotes melanoma development.
    3. SIRT5 promote malignant advancement of chordoma by regulating the desuccinylation of c-myc.
      Title: SIRT5 promote malignant advancement of chordoma by regulating the desuccinylation of c-myc.
    4. SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.
      Title: SIRT5 rs12216101 T>G variant is associated with liver damage and mitochondrial dysfunction in patients with non-alcoholic fatty liver disease.
    5. LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer.
      Title: LDHA Desuccinylase Sirtuin 5 as A Novel Cancer Metastatic Stimulator in Aggressive Prostate Cancer.
    6. Role of SIRT5 in cancer. Friend or Foe?
      Title: Role of SIRT5 in cancer. Friend or Foe?
    7. The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease.
      Title: The deacylase sirtuin 5 reduces malonylation in nonmitochondrial metabolic pathways in diabetic kidney disease.
    8. Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection.
      Title: Emerging Roles of SIRT5 in Metabolism, Cancer, and SARS-CoV-2 Infection.
    9. Circ-ATL1 silencing reverses the activation effects of SIRT5 on smooth muscle cellular proliferation, migration and contractility in intracranial aneurysm by adsorbing miR-455.
      Title: Circ-ATL1 silencing reverses the activation effects of SIRT5 on smooth muscle cellular proliferation, migration and contractility in intracranial aneurysm by adsorbing miR-455.
    10. SIRT5 reduces the inflammatory response and barrier dysfunction in IL-17A-induced epidermal keratinocytes.
      Title: SIRT5 reduces the inflammatory response and barrier dysfunction in IL-17A-induced epidermal keratinocytes.
    Submit: New GeneRIF Correction See all GeneRIFs (85)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36950

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables NAD+ binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables NAD+ binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT enables NAD+-protein ADP-ribosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    NOT enables NAD+-protein poly-ADP-ribosyltransferase activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables NAD-dependent protein lysine deacetylase activity TAS
    Traceable Author Statement
    more info
    		  
    enables histone deacetylase activity, NAD-dependent IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutaryllysine deglutarylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-glutaryllysine deglutarylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-malonyllysine demalonylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-malonyllysine demalonylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-succinyllysine desuccinylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-succinyllysine desuccinylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrion organization TAS
    Traceable Author Statement
    more info
    		  
    involved_in negative regulation of cardiac muscle cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of reactive oxygen species metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-lysine demalonylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peptidyl-lysine desuccinylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in protein deacetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deacetylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein deglutarylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein demalonylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein desuccinylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of ketone biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    		  
    located_in mitochondrion HTP PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    NAD-dependent protein deacylase sirtuin-5, mitochondrial
    Names
    NAD-dependent deacetylase sirtuin-5
    NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial
    silent mating type information regulation 2, S.cerevisiae, homolog 5
    sir2-like 5
    sirtuin type 5
    NP_001180196.1
    NP_001229756.1
    NP_001363727.1
    NP_001363728.1
    NP_001363729.1
    NP_001363730.1
    NP_001363731.1
    NP_001363732.1
    NP_001363733.1
    NP_001363734.1
    NP_001363735.1
    NP_001363736.1
    NP_001363737.1
    NP_001363738.1
    NP_001363739.1
    NP_001363740.1
    NP_001363741.1
    NP_001363742.1
    NP_001363743.1
    NP_001363744.1
    NP_036373.1
    NP_112534.1
    XP_016866109.1
    XP_016866113.1
    XP_024302156.1
    XP_047274470.1
    XP_047274471.1
    XP_047274472.1
    XP_047274473.1
    XP_047274474.1
    XP_047274475.1
    XP_047274476.1
    XP_047274477.1
    XP_047274478.1
    XP_047274479.1
    XP_047274480.1
    XP_047274481.1
    XP_047274482.1
    XP_047274483.1
    XP_054210899.1
    XP_054210900.1
    XP_054210901.1
    XP_054210902.1
    XP_054210903.1
    XP_054210904.1
    XP_054210905.1
    XP_054210906.1
    XP_054210907.1
    XP_054210908.1
    XP_054210909.1
    XP_054210910.1
    XP_054210911.1
    XP_054210912.1
    XP_054210913.1
    XP_054210914.1
    XP_054210915.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001193267.2 → NP_001180196.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AK302467, AL441883, BC000126, CB155518
      Consensus CDS
      CCDS54966.1
      UniProtKB/TrEMBL
      A0A7P0T915
      Related
      ENSP00000352830.3, ENST00000359782.8
      Conserved Domains (1) summary
      cd01412
      Location:51 → 283
      SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...

    2. NM_001242827.1 → NP_001229756.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 4

      See identical proteins and their annotated locations for NP_001229756.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' region, resulting in a downstream AUG start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1. Variants 4 and 19 both encode the same isoform (4).
      Source sequence(s)
      AK294162, AL441883, CB155518
      UniProtKB/Swiss-Prot
      Q9NXA8
      Conserved Domains (1) summary
      cl00195
      Location:4 → 193
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    3. NM_001376798.1 → NP_001363727.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variants 1 and 6-14, encodes isoform 1.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS4526.1
      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915
      Related
      ENSP00000380509.3, ENST00000397350.7
      Conserved Domains (1) summary
      cd01412
      Location:51 → 301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    4. NM_001376799.1 → NP_001363728.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 1, 5, and 7-14, encodes isoform 1.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS4526.1
      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915
      Related
      ENSP00000505496.1, ENST00000680432.1
      Conserved Domains (1) summary
      cd01412
      Location:51 → 301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    5. NM_001376800.1 → NP_001363729.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 1, 5, 6, and 8-14, encodes isoform 1.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS4526.1
      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915
      Conserved Domains (1) summary
      cd01412
      Location:51 → 301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    6. NM_001376801.1 → NP_001363730.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1, 5-7, and 9-14, encodes isoform 1.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS4526.1
      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915
      Conserved Domains (1) summary
      cd01412
      Location:51 → 301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    7. NM_001376802.1 → NP_001363731.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1, 5-8, and 10-14, encodes isoform 1.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS4526.1
      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915
      Conserved Domains (1) summary
      cd01412
      Location:51 → 301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    8. NM_001376803.1 → NP_001363732.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 1, 5-9, and 11-14, encodes isoform 1.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS4526.1
      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915
      Conserved Domains (1) summary
      cd01412
      Location:51 → 301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    9. NM_001376804.1 → NP_001363733.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 1, 5-10, and 12-14, encodes isoform 1.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS4526.1
      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915
      Conserved Domains (1) summary
      cd01412
      Location:51 → 301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    10. NM_001376805.1 → NP_001363734.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 1, 5-11, 13, and 14, encodes isoform 1.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS4526.1
      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915
      Conserved Domains (1) summary
      cd01412
      Location:51 → 301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    11. NM_001376806.1 → NP_001363735.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 1, 5-12, and 14, encodes isoform 1.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS4526.1
      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915
      Related
      ENSP00000505086.1, ENST00000680151.1
      Conserved Domains (1) summary
      cd01412
      Location:51 → 301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    12. NM_001376807.1 → NP_001363736.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 1 and 5-13, encodes isoform 1.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS4526.1
      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915
      Conserved Domains (1) summary
      cd01412
      Location:51 → 301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    13. NM_001376808.1 → NP_001363737.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS4527.1
      UniProtKB/TrEMBL
      A0A7P0T915
      Related
      ENSP00000505469.1, ENST00000680707.1
      Conserved Domains (1) summary
      cd01412
      Location:51 → 285
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    14. NM_001376809.1 → NP_001363738.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 17, encodes isoform 5.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS93861.1
      UniProtKB/TrEMBL
      A0A7P0T9N1
      Related
      ENSP00000505415.1, ENST00000681012.1
      Conserved Domains (1) summary
      cl00195
      Location:51 → 183
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    15. NM_001376810.1 → NP_001363739.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variant 16, encodes isoform 5.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS93861.1
      UniProtKB/TrEMBL
      A0A7P0T9N1
      Related
      ENSP00000505733.1, ENST00000680402.1
      Conserved Domains (1) summary
      cl00195
      Location:51 → 183
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    16. NM_001376811.1 → NP_001363740.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL441883
      Conserved Domains (1) summary
      cd01412
      Location:12 → 262
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    17. NM_001376812.1 → NP_001363741.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variant 4, encodes isoform 4.
      Source sequence(s)
      AL441883
      Conserved Domains (1) summary
      cl00195
      Location:4 → 193
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    18. NM_001376813.1 → NP_001363742.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20), as well as variant 21, encodes isoform 7.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS93862.1
      UniProtKB/TrEMBL
      A0A7P0T877, A0A7P0Z4N6
      Related
      ENSP00000506431.1, ENST00000681243.1
      Conserved Domains (1) summary
      cl00195
      Location:51 → 158
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    19. NM_001376814.1 → NP_001363743.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variant 20, encodes isoform 7.
      Source sequence(s)
      AL441883
      Consensus CDS
      CCDS93862.1
      UniProtKB/TrEMBL
      A0A7P0T877, A0A7P0Z4N6
      Conserved Domains (1) summary
      cl00195
      Location:51 → 158
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    20. NM_001376815.1 → NP_001363744.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL441883

    21. NM_012241.5 → NP_036373.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 1

      See identical proteins and their annotated locations for NP_036373.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 5-14 all encode the same protein.
      Source sequence(s)
      AF083110, AL441883, BC000126, DC314190
      Consensus CDS
      CCDS4526.1
      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915
      Related
      ENSP00000476228.1, ENST00000606117.2
      Conserved Domains (1) summary
      cd01412
      Location:51 → 301
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    22. NM_031244.3 → NP_112534.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_112534.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains a distinct 5' UTR, C-terminal coding region, and 3' UTR as compared to transcript variant 1. This variant encodes isoform 2 which has a distinct and shorter C-terminus than isoform 1. Variants 2 and 15 both encode the same isoform (2).
      Source sequence(s)
      AJ420496, AK000355, CB155518
      Consensus CDS
      CCDS4527.1
      UniProtKB/TrEMBL
      A0A7P0T915
      Related
      ENSP00000368564.4, ENST00000379262.8
      Conserved Domains (1) summary
      cd01412
      Location:51 → 285
      SIRT5_Af1_CobB; Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD ...

    RNA

    1. NR_164852.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL441883

    2. NR_164853.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL441883

    3. NR_164854.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL441883
      Related
      ENST00000379250.10

    4. NR_164856.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL441883
      Related
      ENST00000681905.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      13574274..13615158
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047418519.1 → XP_047274475.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A7P0T915

    2. XM_047418522.1 → XP_047274478.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A7P0T915

    3. XM_047418520.1 → XP_047274476.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A7P0T915

    4. XM_024446388.2 → XP_024302156.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X6

      UniProtKB/TrEMBL
      A0A7P0TBF5
      Conserved Domains (1) summary
      cl00195
      Location:51 → 183
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    5. XM_017010620.3 → XP_016866109.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A7P0T915
      Related
      ENSP00000505346.1, ENST00000680852.1
      Conserved Domains (1) summary
      cd01412
      Location:51 → 291
      SIRT5_Af1_CobB; SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which ...

    6. XM_017010624.3 → XP_016866113.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0A7P0TBF5
      Conserved Domains (1) summary
      cl00195
      Location:51 → 183
      SIR2; SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+, ...

    7. XM_047418515.1 → XP_047274471.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915

    8. XM_047418516.1 → XP_047274472.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915

    9. XM_047418527.1 → XP_047274483.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A7P0T9N1

    10. XM_047418514.1 → XP_047274470.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915

    11. XM_047418526.1 → XP_047274482.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A7P0T9N1

    12. XM_047418525.1 → XP_047274481.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A7P0T9N1

    13. XM_047418518.1 → XP_047274474.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A7P0T915

    14. XM_047418517.1 → XP_047274473.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A7P0T915

    15. XM_047418523.1 → XP_047274479.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A7P0T915

    16. XM_047418524.1 → XP_047274480.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A7P0T915

    17. XM_047418521.1 → XP_047274477.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A7P0T915

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      13447831..13488715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054354928.1 → XP_054210903.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A7P0T915

    2. XM_054354932.1 → XP_054210907.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A7P0T915

    3. XM_054354929.1 → XP_054210904.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A7P0T915

    4. XM_054354935.1 → XP_054210910.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A7P0T915

    5. XM_054354940.1 → XP_054210915.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X6

      UniProtKB/TrEMBL
      A0A7P0TBF5

    6. XM_054354934.1 → XP_054210909.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A7P0T915

    7. XM_054354939.1 → XP_054210914.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0A7P0TBF5

    8. XM_054354925.1 → XP_054210900.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915

    9. XM_054354938.1 → XP_054210913.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A7P0T9N1

    10. XM_054354924.1 → XP_054210899.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915

    11. XM_054354937.1 → XP_054210912.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A7P0T9N1

    12. XM_054354936.1 → XP_054210911.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X4

      UniProtKB/TrEMBL
      A0A7P0T9N1

    13. XM_054354930.1 → XP_054210905.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A7P0T915

    14. XM_054354927.1 → XP_054210902.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X2

      UniProtKB/TrEMBL
      A0A7P0T915

    15. XM_054354933.1 → XP_054210908.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A7P0T915

    16. XM_054354931.1 → XP_054210906.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X3

      UniProtKB/TrEMBL
      A0A7P0T915

    17. XM_054354926.1 → XP_054210901.1  NAD-dependent protein deacylase sirtuin-5, mitochondrial isoform X1

      UniProtKB/Swiss-Prot
      B4DFM4, B4DYJ5, F5H5Z9, Q5T294, Q5T295, Q9NXA8, Q9Y6E6
      UniProtKB/TrEMBL
      A0A7P0T915
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NXA8.2 GenPept UniProtKB/Swiss-Prot:Q9NXA8

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