Maf1 MAF1 homolog, negative regulator of RNA polymerase III [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Maf1provided by RGD
Official Full Name: MAF1 homolog, negative regulator of RNA polymerase IIIprovided by RGD
Primary source: RGD:1359315
See related: EnsemblRapid:ENSRNOG00000013514 AllianceGenome:RGD:1359315
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables GABA receptor binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase I and negative regulation of transcription by RNA polymerase III. Located in several cellular components, including dendrite; inhibitory synapse; and perinuclear region of cytoplasm. Orthologous to human MAF1 (MAF1 homolog, negative regulator of RNA polymerase III). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Muscle (RPKM 570.0), Heart (RPKM 489.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (109955876..109958909)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (108075173..108078252)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (117417643..117420722)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We report the characterisation of the proteins Maf1 and Macoco in the brain, which we identify as novel GABAAR beta-subunit interacting proteins.
Title: Identification and characterisation of a Maf1/Macoco protein complex that interacts with GABAA receptors in neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

Maf (e-PCR), detects polymorphism
- UniSTS:531342

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GABA receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase III core binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase III type 1 promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III type 1 promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase III type 2 promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III type 2 promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase III type 3 promoter sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in negative regulation of transcription by RNA polymerase I	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase III	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase III	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase III	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in inhibitory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: repressor of RNA polymerase III transcription MAF1 homolog

Names: MAF1 negative regulator of RNA polymerase III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014085.1 → NP_001014107.1 repressor of RNA polymerase III transcription MAF1 homolog

See identical proteins and their annotated locations for NP_001014107.1

Status: PROVISIONAL

Source sequence(s)

BC083712

UniProtKB/Swiss-Prot

Q5XIH0

UniProtKB/TrEMBL

A6HS93

Related

ENSRNOP00000089214.2, ENSRNOT00000098036.2

Conserved Domains (1) summary

pfam09174
Location:25 → 202

Maf1; Maf1 regulator

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

109955876..109958909

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063263594.1 → XP_063119664.1 repressor of RNA polymerase III transcription MAF1 homolog isoform X2
XM_063263595.1 → XP_063119665.1 repressor of RNA polymerase III transcription MAF1 homolog isoform X5
XM_006241811.3 → XP_006241873.1 repressor of RNA polymerase III transcription MAF1 homolog isoform X4

Conserved Domains (1) summary

pfam09174
Location:17 → 191

Maf1; Maf1 regulator
XM_063263596.1 → XP_063119666.1 repressor of RNA polymerase III transcription MAF1 homolog isoform X7

Related

ENSRNOP00000018240.7, ENSRNOT00000018240.7
XM_063263593.1 → XP_063119663.1 repressor of RNA polymerase III transcription MAF1 homolog isoform X1
XM_039079243.2 → XP_038935171.1 repressor of RNA polymerase III transcription MAF1 homolog isoform X3

Conserved Domains (1) summary

pfam09174
Location:25 → 202

Maf1; Maf1 regulator
XM_006241812.2 → XP_006241874.1 repressor of RNA polymerase III transcription MAF1 homolog isoform X6

UniProtKB/TrEMBL

A0A8L2Q923

Conserved Domains (1) summary

pfam09174
Location:25 → 202

Maf1; Maf1 regulator