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    MIR194-2HG MIR194-2 host gene [ Homo sapiens (human) ]

    Gene ID: 105369343, updated on 10-Dec-2024

    Summary

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    Official Symbol
    MIR194-2HGprovided by HGNC
    Official Full Name
    MIR194-2 host geneprovided by HGNC
    Primary source
    HGNC:HGNC:51946
    See related
    Ensembl:ENSG00000229719 AllianceGenome:HGNC:51946
    Gene type
    ncRNA
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Expression
    Biased expression in small intestine (RPKM 9.0), duodenum (RPKM 8.0) and 4 other tissues See more
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    Genomic context

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    See MIR194-2HG in Genome Data Viewer
    Location:
    11q13.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (64888458..64893449, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (64881697..64886688, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (64655930..64660921, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene EH domain containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4930 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4932 Neighboring gene microRNA 10392 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64650863-64651364 Neighboring gene ribosomal protein S16 pseudogene 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:64654864-64655434 Neighboring gene microRNA 194-2 Neighboring gene microRNA 192 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4933 Neighboring gene autophagy related 2A Neighboring gene microRNA 6750 Neighboring gene microRNA 6749

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Inducible expression of microRNA-194 is regulated by HNF-1alpha during intestinal epithelial cell differentiation. Hino K, et al. RNA, 2008 Jul. PMID 18492795, Free PMC Article
    2. Downregulation of serum miR-194 predicts poor prognosis in osteosarcoma patients. Shi L, et al. Ann Diagn Pathol, 2020 Jun. PMID 32172218
    3. miR-194 as predictive biomarker of responsiveness to neoadjuvant chemoradiotherapy in patients with locally advanced rectal adenocarcinoma. D'Angelo E, et al. J Clin Pathol, 2018 Apr. PMID 28870889
    4. miR-194-5p inhibits SLC40A1 expression to induce cisplatin resistance in ovarian cancer. Wu J, et al. Pathol Res Pract, 2020 Jul. PMID 32534701
    5. miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein. Zhu X, et al. Oncotarget, 2016 Mar 15. PMID 26909612, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of serum miR-194 predicts poor prognosis in osteosarcoma patients.
      Title: Downregulation of serum miR-194 predicts poor prognosis in osteosarcoma patients.
    2. miR-194-5p inhibits SLC40A1 expression to induce cisplatin resistance in ovarian cancer.
      Title: miR-194-5p inhibits SLC40A1 expression to induce cisplatin resistance in ovarian cancer.
    3. The present study...identified miR-194 as predictive biomarker of response to preoperative chemoradiotherapy for locally advanced rectal cancer
      Title: miR-194 as predictive biomarker of responsiveness to neoadjuvant chemoradiotherapy in patients with locally advanced rectal adenocarcinoma.
    4. These findings suggested that miR-194 inhibits proliferation and metastasis and reverses cisplatin-resistance of non-small cell lung cancer cells
      Title: miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein.
    5. miR-194 regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of MAP4K4
      Title: MicroRNA-194 acts as a prognostic marker and inhibits proliferation in hepatocellular carcinoma by targeting MAP4K4.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    General gene information

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    Other Names

    • pri-microRNA-194-2, -192

    Clone Names

    • FLJ26898, AP001187.9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    RNA

    1. NR_133638.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AK092802, AP001187

    2. NR_133639.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate splice site in the 5' region and differs in the 3' exon structure, resulting in a shorter transcript than variant 1.
      Source sequence(s)
      AP001187
      Related
      ENST00000710930.1

    3. NR_133640.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) contains an alternate splice site in the 5' region and differs in the 3' exon structure, resulting in a shorter transcript than variant 1.
      Source sequence(s)
      AP001187
      Related
      ENST00000710929.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      64888458..64893449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      64881697..64886688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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    Research Materials