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    Txndc11 thioredoxin domain containing 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 302899, updated on 27-Nov-2024

    Summary

    Official Symbol
    Txndc11provided by RGD
    Official Full Name
    thioredoxin domain containing 11provided by RGD
    Primary source
    RGD:1307538
    See related
    EnsemblRapid:ENSRNOG00000002452 AllianceGenome:RGD:1307538
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307538
    Summary
    Predicted to be located in membrane. Orthologous to human TXNDC11 (thioredoxin domain containing 11). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Spleen (RPKM 83.2), Thymus (RPKM 78.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Txndc11 in Genome Data Viewer
    Location:
    10q11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (5022464..5079958)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (4515457..4572999)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (4578469..4635963)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene ribosomal L1 domain containing 1 Neighboring gene zinc finger CCCH type containing 7 A Neighboring gene uncharacterized LOC134480745 Neighboring gene stannin Neighboring gene BCL2 like 12, pseudogene 2 Neighboring gene mRNA turnover 4, ribosome maturation factor, pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General protein information

    Preferred Names
    thioredoxin domain-containing protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001127532.1NP_001121004.1  thioredoxin domain-containing protein 11

      See identical proteins and their annotated locations for NP_001121004.1

      Status: PROVISIONAL

      Source sequence(s)
      BC166713
      UniProtKB/TrEMBL
      A0A8I5ZQI0, B2RYB1, E9PSP7
      Related
      ENSRNOP00000003332.6, ENSRNOT00000003332.8
      Conserved Domains (4) summary
      cd02981
      Location:215319
      PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02995
      Location:660762
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      cd03006
      Location:93205
      PDI_a_EFP1_N; PDIa family, N-terminal EFP1 subfamily; EFP1 is a binding partner protein of thyroid oxidase (ThOX), also called Duox. ThOX proteins are responsible for the generation of hydrogen peroxide, a crucial substrate of thyroperoxidase, which functions to ...
      pfam13848
      Location:254396
      Thioredoxin_6; Thioredoxin-like domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      5022464..5079958
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008767481.4XP_008765703.1  thioredoxin domain-containing protein 11 isoform X1

      UniProtKB/TrEMBL
      A0A8I6G9N1
      Conserved Domains (4) summary
      cd02981
      Location:80184
      PDI_b_family; Protein Disulfide Isomerase (PDIb) family, redox inactive TRX-like domain b; composed of eukaryotic proteins involved in oxidative protein folding in the endoplasmic reticulum (ER) by acting as catalysts and folding assistants. Members of this family ...
      cd02995
      Location:525627
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...
      pfam13848
      Location:119261
      Thioredoxin_6; Thioredoxin-like domain
      cl00388
      Location:1970
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    2. XM_039085803.2XP_038941731.1  thioredoxin domain-containing protein 11 isoform X2

      Conserved Domains (2) summary
      COG1196
      Location:489598
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd02995
      Location:356458
      PDI_a_PDI_a'_C; PDIa family, C-terminal TRX domain (a') subfamily; composed of the C-terminal redox active a' domains of PDI, ERp72, ERp57 (or ERp60) and EFP1. PDI, ERp72 and ERp57 are endoplasmic reticulum (ER)-resident eukaryotic proteins involved in oxidative protein ...

    RNA

    1. XR_010055165.1 RNA Sequence