Tmem201 transmembrane protein 201 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tmem201provided by RGD
Official Full Name: transmembrane protein 201provided by RGD
Primary source: RGD:1583947
See related: EnsemblRapid:ENSRNOG00000023152 AllianceGenome:RGD:1583947
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin filament binding activity and lamin binding activity. Predicted to be involved in several processes, including centrosome localization; nuclear migration along microtubule; and protein localization to nuclear envelope. Predicted to act upstream of or within fibroblast migration and nuclear migration. Predicted to be located in cortical endoplasmic reticulum; nuclear inner membrane; and spindle pole centrosome. Predicted to be active in nuclear membrane. Orthologous to human TMEM201 (transmembrane protein 201). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Heart (RPKM 37.1), Muscle (RPKM 28.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (165449270..165471901, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (160166240..160188874, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (166672700..166695288, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	ISO Inferred from Sequence Orthology more info
enables lamin binding	IBA Inferred from Biological aspect of Ancestor more info
enables lamin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in centrosome localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in nuclear envelope organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within nuclear migration	ISO Inferred from Sequence Orthology more info
involved_in nuclear migration along microtubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to nuclear envelope	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cortical endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
located_in nuclear inner membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear inner membrane	ISO Inferred from Sequence Orthology more info
is_active_in nuclear membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in spindle pole centrosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transmembrane protein 201

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001431302.1 → NP_001418231.1 transmembrane protein 201 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

D3ZBW3
NM_001431303.1 → NP_001418232.1 transmembrane protein 201 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A6IUC1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

165449270..165471901 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001078224.7 → XP_001078224.2 transmembrane protein 201

Related

ENSRNOP00000048083.5, ENSRNOT00000047763.8

Conserved Domains (2) summary

pfam09779
Location:47 → 169

Ima1_N; Ima1 N-terminal domain

pfam10476
Location:192 → 379

DUF2448; Protein of unknown function C-terminus (DUF2448)